PreOp Meds: PPI concepts Flashcards

1
Q

How do proton pump inhibitors work?
What is the onset of action for proton pump inhibitors?

A
  • Irreversible binding to H⁺ pumps preventing acid creation.
  • 3-5 days for full result.
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2
Q

What is the most effective drug for controlling gastric acidity and volume?

A
  • PPI’s
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3
Q

For what four conditions are PPI’s indicated?

A
  • Esophagitis
  • Ulceration
  • GERD
  • Zollinger-Ellison (excess acid)
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4
Q

What coagulation considerations have to be made with PPI’s?

A
  • PPI’s inhibit warfarin metabolism = warfarin overdose
  • PPI’s block clopidogrel = plavix won’t work.
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5
Q

In what situations is an H2 blocker preferred over a PPI?

A
  • Aspiration Pneumonitis possibility (H2 blocker works faster)
  • Intermittent symptoms
  • Cost
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6
Q

In what situations are PPI’s superior to H2 blockers?

A
  • Any ulcerations
  • GERD
  • Acute upper GI hemmorhage
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7
Q

What five serious conditions have been associated with PPI’s?

A
  • Bone fractures
  • Lupus
  • Acute interstitial nephritis
  • C-diff
  • Deficient Vit B12 & Mg⁺⁺
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