PreOp Meds: 5HT3 Antagonists & Ondansetron (Zofran) Flashcards

1
Q

Where is serotonin released from and how does it cause emesis?

A
  • Released via chromaffin cells of small intestine → vagal stimulation via 5HT3 receptors
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2
Q

Where are the highest concentration of serotonin receptors found?

Where else are they commonly found?

A
  • Brain & GI tract
  • Kidney, liver, lung, stomach
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3
Q

What is the greatest general benefit of 5HT3 antagonists?
What are they not useful for?

A
  • Very few side effects
  • Not useful for motion sickness
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4
Q

What is the E ½ time of Ondansetron? Why is this relevant?

A
  • 4 hours: dose must be given so that effect peaks towards end of the case.
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5
Q

What is the normal dose of Ondansetron?

A
  • 4 - 8 mg IV
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6
Q

If side effects are seen with ondansetron, what might be seen?

A
  • Slight QT prolongation, headache, diarrhea
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