Induction Meds: Methohexital (Oxybarbiturates) Flashcards

1
Q

At a normal pH _______% of methohexital is non-ionized.

At a normal pH ____% of sodium pentothal is non-ionized.

What does this mean in regards to induction for comparing these drugs?

A
  • 76% non-ionized Methohexital
  • 61% non-ionized Sodium Pentothal
  • Methohexital for induction has a faster metabolism and recovery due to its increased lipid-solubility.

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2
Q

Which barbiturate causes excitatory symptoms like myoclonus and hiccups?

A

Methohexital

S29

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3
Q

How would methohexital infusions differ from induction?

A

Very lipid-soluble so:

  • Drug persists from infusion but clears quickly from induction.

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4
Q

What is the IV methohexital dose?

A

1.5 mg/kg IV

S30

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5
Q

What is the seizure profile of methohexital?

A

Can induce seizures but is better than etomidate or when used with ECT.

  1. Continuous infusions induce post-op seizures in ⅓ of patients.
  2. Seizures are induced in patients undergoing temporal lobe resection.
  3. Seizure duration reduced 35-45% in ECT patients vs etomidate.

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6
Q

What is per rectum dose of Methohexital?

A

20 - 30 mg/kg PR

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