Induction Meds: Methohexital (Oxybarbiturates) Flashcards
1
Q
At a normal pH _______% of methohexital is non-ionized.
At a normal pH ____% of sodium pentothal is non-ionized.
What does this mean in regards to induction for comparing these drugs?
A
- 76% non-ionized Methohexital
- 61% non-ionized Sodium Pentothal
- Methohexital for induction has a faster metabolism and recovery due to its increased lipid-solubility.
S27
2
Q
Which barbiturate causes excitatory symptoms like myoclonus and hiccups?
A
Methohexital
S29
3
Q
How would methohexital infusions differ from induction?
A
Very lipid-soluble so:
- Drug persists from infusion but clears quickly from induction.
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4
Q
What is the IV methohexital dose?
A
1.5 mg/kg IV
S30
5
Q
What is the seizure profile of methohexital?
A
Can induce seizures but is better than etomidate or when used with ECT.
- Continuous infusions induce post-op seizures in ⅓ of patients.
- Seizures are induced in patients undergoing temporal lobe resection.
- Seizure duration reduced 35-45% in ECT patients vs etomidate.
S30
6
Q
What is per rectum dose of Methohexital?
A
20 - 30 mg/kg PR
S30