Induction Meds: Opioids Agonist - Morphine Flashcards

1
Q

What is the dosage of Morphine?

A

1 - 10 mg IV

S22/28

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2
Q

How is Morphine metabolized?
What are the metabolites and their significance?

A
  • Glucuronidation in the liver

metabolites:
- Morphine-6-glucuronide = (5-25%) but is an active anaglesic causing late resp depression.

  • Morphine-3-glucuronide (75% to 95%) but inactive

S29

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3
Q

What would occur with Morphine overdose in a renal failure patient?

A

Prolonged ventilatory depression.

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4
Q

Morphine tends to relieve _____ type pain more than _____ type pain.

A

Dull: sharp

S27

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5
Q

What is the onset of Morphine?

A

10 - 20 mins

S28

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6
Q

What is the IM and IV peak of Morphine?

A

IM: 45 to 90 mins

IV: 15-30 mins

S28

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7
Q

Morphine is ____ standard with opioids

A

Gold standard

S27

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8
Q

What effects does Morphine have?

A
  • Analgesia
  • euphoria
  • sedation,
  • diminished ability to concentrate
  • nausea
  • feeling of body warmth
  • heaviness of extremities,
  • dryness of the mouth
  • pruritis.

S27

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9
Q

What areas of the body does Morphine relieve?

A
  • visceral
  • skeletal muscles
  • joints and integumental dull > sharp
  • intermittent pain

S27

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10
Q

What is the duration of Morphine?

A

4-5 hours

S28

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11
Q

What are the first past effects of Morphine in the liver and lungs?

A
  • PO Hepatic 1st Pass: 25%.
  • No first pass uptake in lungs

S28

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12
Q

Where does Morphine accumulate rapidly?

A
  • kidneys
  • liver
  • skeletal muscles

S28

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13
Q

What is the elimination 1/2 time of Morphine?

A

longer with morphine-3-glucuronide

S30

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14
Q

Which gender has more analgesic potency and slower speed of offset with Morphine?

A

Women

S30

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