Induction Meds: Opioids Agonist - Morphine Flashcards
What is the dosage of Morphine?
1 - 10 mg IV
S22/28
How is Morphine metabolized?
What are the metabolites and their significance?
- Glucuronidation in the liver
metabolites:
- Morphine-6-glucuronide = (5-25%) but is an active anaglesic causing late resp depression.
- Morphine-3-glucuronide (75% to 95%) but inactive
S29
What would occur with Morphine overdose in a renal failure patient?
Prolonged ventilatory depression.
Morphine tends to relieve _____ type pain more than _____ type pain.
Dull: sharp
S27
What is the onset of Morphine?
10 - 20 mins
S28
What is the IM and IV peak of Morphine?
IM: 45 to 90 mins
IV: 15-30 mins
S28
Morphine is ____ standard with opioids
Gold standard
S27
What effects does Morphine have?
- Analgesia
- euphoria
- sedation,
- diminished ability to concentrate
- nausea
- feeling of body warmth
- heaviness of extremities,
- dryness of the mouth
- pruritis.
S27
What areas of the body does Morphine relieve?
- visceral
- skeletal muscles
- joints and integumental dull > sharp
- intermittent pain
S27
What is the duration of Morphine?
4-5 hours
S28
What are the first past effects of Morphine in the liver and lungs?
- PO Hepatic 1st Pass: 25%.
- No first pass uptake in lungs
S28
Where does Morphine accumulate rapidly?
- kidneys
- liver
- skeletal muscles
S28
What is the elimination 1/2 time of Morphine?
longer with morphine-3-glucuronide
S30
Which gender has more analgesic potency and slower speed of offset with Morphine?
Women
S30