Induction Meds: Opioids Agonist - Sufentanil Flashcards

1
Q

How much more potent is Sufentanil than Fentanyl?

A

5-12 times more potent.

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1
Q

How much of Sufentanil is subject to first pass effects?

A

60% lung first-pass

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2
Q

How much of Sufentanil is protein bound? What protein is it bound to?

A

92.5% α-1 acid glycoprotein bound.

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3
Q

What is the analgesia dose of Sufentanil?

A

0.1 - 0.4 μg/kg IV

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4
Q

What is the induction dose of sufentanil?

A

18.9 mcg/kg IV

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5
Q

What is the metabolism and excretion of Sufentanil?

A

Metabolism: hepatic

Excretion: renal and fecal (caution in chronic renal failure)

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6
Q

What is the context-sensitive half-time and Vd of Sufentanil?

A
  • Context-sensitive half-time: shorter
  • larger Vd > alfentanil

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7
Q

What is the intraop dose of Sufentanil?

A

0.3 to 1 µg/kg IV

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8
Q

What is the infusion dose of Sufentanil?

A

0.5 to 1 µg/kg/hr IV

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9
Q

What are the side effects of Sufentanil?

A
  • Bradycardia (↓ C.O.)
  • Rigidity chest wall and abdominal muscles)

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