Induction Meds: Opioids Agonist - Alfentanil Flashcards

1
Q

What is the potency of Alfentanil?
What is its onset?

A
  • 20% as potent as Fentanyl
  • Onset: 1.4 min (faster than all derivatives except Remifentanil)

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2
Q

What is the Alfentanil induction dose?

A

Induction: 150 - 300 mcg /kg IV

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3
Q

What drug can cause acute dystonia when given to a Parkinson’s patient?

A

Alfentanil

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4
Q

What is laryngoscopy dose of Alfentanil?

A

15 - 30 mcg/kg IV (90 seconds prior)

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5
Q

What about is the maintenance dose of Alfentanil?

A

25 - 150 mcg/kg/hr with inhaled anesthetics

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6
Q

What are the pharmacokinetics of Alfentanil?

A
  • Cirrhosis: prolongs elimination half-time
  • 90% nonionized at normal pH –> lower lipid solubility
  • Higher protein binding
  • Metabolite: Noralfentanil (Hepatic P450 3A4)

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