Induction Meds: Opioids Antagonist - Naloxone Flashcards

1
Q

What receptors is Naloxone effective on?

A
  • μ, κ, δ (non-selective)

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2
Q

What non-opioid uses does Naloxone have?

A
  • ↑ contractility for shock
  • Antagonism of general anesthesia (at high doses)
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3
Q

What is the naloxone IV push dose?
Continuous infusion?

A

1-4 mcg/kg IVP

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4
Q

What dose of naloxone is use for shock?

A

> 1mg/kg IV

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5
Q

How long does Naloxone last?

A
  • 30 - 45 minutes

Often needs redosing for overdoses.

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6
Q

What are the possible side-effects of naloxone?

A
  • Analgesia reversal
  • N/V
  • ↑ SNS ( ↑ HR, BP, dysrhythmias, etc.)

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7
Q

What are the uses of Naloxone?

A
  • opioid-induced depression in post op
  • neonate* (from mom)
  • opioid overdose
  • detect dependence

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8
Q

What is the continuous infusion of Naloxone?

A

5 mcg/kg IV infusion

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9
Q

What dose will cause epidural side effect of Naloxone?

A

0.25 µg/kg/hour IV

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10
Q

Where is Naloxone metabolized and the first pass effect?

A

metabolized in Liver (glucorinic acid)

1/5th PO Hepatic first pass

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11
Q

What is the elimination 1/2 time of Naloxone?

A

60 to 90 mins

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