Induction Meds: Opioids Antagonist - Naloxone Flashcards
What receptors is Naloxone effective on?
- μ, κ, δ (non-selective)
S19
What non-opioid uses does Naloxone have?
- ↑ contractility for shock
- Antagonism of general anesthesia (at high doses)
What is the naloxone IV push dose?
Continuous infusion?
1-4 mcg/kg IVP
S20
What dose of naloxone is use for shock?
> 1mg/kg IV
How long does Naloxone last?
- 30 - 45 minutes
Often needs redosing for overdoses.
S20
What are the possible side-effects of naloxone?
- Analgesia reversal
- N/V
- ↑ SNS ( ↑ HR, BP, dysrhythmias, etc.)
S20
What are the uses of Naloxone?
- opioid-induced depression in post op
- neonate* (from mom)
- opioid overdose
- detect dependence
S19
What is the continuous infusion of Naloxone?
5 mcg/kg IV infusion
S20
What dose will cause epidural side effect of Naloxone?
0.25 µg/kg/hour IV
S20
Where is Naloxone metabolized and the first pass effect?
metabolized in Liver (glucorinic acid)
1/5th PO Hepatic first pass
S20
What is the elimination 1/2 time of Naloxone?
60 to 90 mins
S20