Flashcards in 2- Connective Tissue Diseases Deck (22)
What is the basic pathology behind CTDs?
Autoimmunity producing antibodies against cells of the body
SLE is more common in whom?
Women 11:1 men
Which antibodies are associated with SLE?
Complement levels are high in active SLE. True/False?
Why is urinalysis done in SLE?
Look for glomerulonephritis
Outline management for mild (skin) SLE
Outline management for moderate SLE
Outline management for severe SLE
What is the basic pathogenesis in Sjogren's syndrome?
Autoimmune destruction of exocrine glands
List clinical features of Sjogren's syndrome
Which autoantibodies are associated with Sjogren's syndrome?
What is the basic pathogenesis in systemic sclerosis?
Excess collagen deposition, causing skin and organ changes
What is the difference between limited and diffuse systemic sclerosis?
Limited - mainly confined skin changes
Diffuse - rapid skin changes and early organ involvement
Which systemic sclerosis - limited or diffuse - is associated with anti-centromere Ab?
Which systemic sclerosis - limited or diffuse - is associated with anti-Scl-70 Ab?
What is a common skin change that occurs in systemic sclerosis?
CREST describes findings in systemic sclerosis - what does it stand for?
List features of mixed CTD
What does antiphospholipid syndrome increase the risk of?
Increased clotting, leading to thrombosis
In females, what is the important common consequence of antiphospholipid syndrome (APS)?
Which immunological factors are associated with APS?