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Flashcards in 2- Connective Tissue Diseases Deck (22)
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1

What is the basic pathology behind CTDs?

Autoimmunity producing antibodies against cells of the body

2

SLE is more common in whom?

Black people
Women 11:1 men

3

Which antibodies are associated with SLE?

ANA
Anti-dsDNA
Anti-Sm
Anti-Ro
Anti-La
Anti-RNP

4

Complement levels are high in active SLE. True/False?

False
Low

5

Why is urinalysis done in SLE?

Look for glomerulonephritis

6

Outline management for mild (skin) SLE

Hydroxychloroquine
Topical steroid
NSAID

7

Outline management for moderate SLE

Immunosuppression
Steroid

8

Outline management for severe SLE

IV steroid
Cyclophosphamide

9

What is the basic pathogenesis in Sjogren's syndrome?

Autoimmune destruction of exocrine glands

10

List clinical features of Sjogren's syndrome

Dry mouth/eyes
Parotid swelling

11

Which autoantibodies are associated with Sjogren's syndrome?

Anti-Ro
Anti-La

12

What is the basic pathogenesis in systemic sclerosis?

Excess collagen deposition, causing skin and organ changes

13

What is the difference between limited and diffuse systemic sclerosis?

Limited - mainly confined skin changes
Diffuse - rapid skin changes and early organ involvement

14

Which systemic sclerosis - limited or diffuse - is associated with anti-centromere Ab?

Limited

15

Which systemic sclerosis - limited or diffuse - is associated with anti-Scl-70 Ab?

Diffuse

16

What is a common skin change that occurs in systemic sclerosis?

Raynaud's phenomenon

17

CREST describes findings in systemic sclerosis - what does it stand for?

Calcinosis
Raynaud's phenomenon
Oeseophageal dysmotility
Sclerodactyly
Telangiectasia

18

List features of mixed CTD

Raynaud's phenomenon
Arthralgia/arthritis
Myositis
Sclerodactyly
Pulmonary hypertension
ILD

19

What does antiphospholipid syndrome increase the risk of?

Increased clotting, leading to thrombosis

20

In females, what is the important common consequence of antiphospholipid syndrome (APS)?

Pregnancy loss

21

Which immunological factors are associated with APS?

Lupus anticoagulant
Anti-cardiolipin antibody
Anti-beta-2-glycoprotein

22

Outline treatment for APS

Anticoagulation for those with thrombosis
LMWH in pregnancy