2- Inflammatory Arthropathies Flashcards Preview

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Flashcards in 2- Inflammatory Arthropathies Deck (33)
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1

List features suggestive of joint inflammation

Joint pain
Swelling
Morning stiffness
Improvement with exercise
Synovitis

2

What is the most prevalent seropositive arthropathy?

Rheumatoid arthritis

3

Men are more affected than women by RA. True/False?

False
Women 3:1 men

4

What age is the typical onset of RA?

35-50yrs

5

There is a genetic component to RA. True/False?

True

6

What is the basic pathogenesis behind RA?

Autoimmunity; synovium becomes inflamed and destroys articular cartilage, causing joint destruction

7

List clinical features of RA

Symmetrical synovitis
Pain
Morning stiffness
Rheumatoid nodules

8

Which joints in the hand are affected my RA?

MCP
PIP
Wrist

9

Which autoantibodies are associated with RA?

Anti-CCP
Rheumatoid factor

10

XR is useful at the onset of RA. True/False?

False
Often shows no joint abnormality in early stages

11

Outline treatment for RA

DMARDs
NSAIDs
Analgesia
Injected/oral steroid
Biologics

12

List the main seronegative arthropathies

Ankylosing spondilitis
Psoriatic arthritis
IBD arthritis
Reactive arthritis

13

Which HLA is often associated with seronegative arthropathies?

HLA-B27

14

Where does ankylosing spondilitis usually affect?

Spine
Sacroiliac joints

15

Who is more affected by AS - males or females?

Males 3:1 females

16

What is the age of onset of AS?

20-40yrs

17

List clinical features of AS

Spinal pain/stiffness
Improvement with exercise
Loss of lumbar lordosis
Increased thoracic kyphosis

18

Which test is used to assess lumbar spine flexion?

Schobers test

19

What does AS show on XR?

Sclerosis/fusion of sacroiliac joints
Syndesmophytes (bony spurs)
"Bamboo spine"

20

Outline treatment for AS

NSAIDs
Physiotherapy
Anti-TNF

21

Psoriatic arthritis is usually symmetrical. True/False?

False

22

What are the main nail changes that occur in psoriatic arthritis?

Onycholysis
Pitting

23

Which GU infections can typically cause reactive arthritis?

Chlamydia
Neisseria

24

Which GI infections can typically cause reactive arthritis?

Salmonella
Campylobacter

25

Which triad of symptoms are included in Reiter's syndrome (a form of reactive arthritis)?

Urethritis
Uveitis/Conjunctivitis
Arthritis

26

What causes gout?

High levels of uric acid, causing deposition of urate crystals within a joint

27

What is uric acid a product of?

The breakdown of purines in DNA metabolism (adenine, guanine)

28

What are gout tophi?

Painless white accumulations of uric acid that can erupt through the skin

29

How do gout crystals appear on polarised microscopy?

Negatively birefringent needle-shaped crystals

30

Outline treatment of acute gout

NSAID/colchicine (for those intolerant of NSAID)
Steroid
Analgesia