Flashcards in 3 Anti-virals Deck (20):
What is the structure of viruses?
Nucleic acid with proteins (coat and enzymes).
What are the 8 steps of viral replication?
Virus attachment. Cell entry. Virus uncoating. Early protein production. Replication. Late protein production. Virus assembly. Virus release.
Which polymerases are unique among viruses?
RNA to RNA (RNA viruses)
RNA to DNA (Retroviruses and Hep B)
What are NRTI's?
Nucleoside Reverse Transcriptase Inhibitor
NRTI's are analogues. What are the thymidine analogues?
Give two examples of non-nucleotide reverse transcriptase inhibitors.
Give two examples of protease inhibitors.
Give an example of a fusion inhibitor
Give an example of an integrase inhibitor
Give an example of a chemokine receptor antagonist (CCR5).
What is HAART?
2 NRTIs + NNRTI
2 NRTIs + boosted PI
Switch of CD4 replication.
Which HIV mutation confers resistance to Lamivudine?
Which gene confers resistance to HIV?
CCR 5 delta 32
What is Aciclovir and what is it used for?
What is Ganciclovir used for?
What is Ribavirin used for?
Hep C and RSV
What are Interferons used for?
Hep C, Hep B
Name a cytosine analogue (NRTI).
Name two purine analogues (NRTIs).