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Flashcards in 3 Anti-virals Deck (20):
1

What is the structure of viruses?

Nucleic acid with proteins (coat and enzymes).

2

What are the 8 steps of viral replication?

Virus attachment. Cell entry. Virus uncoating. Early protein production. Replication. Late protein production. Virus assembly. Virus release.

3

Which polymerases are unique among viruses?

RNA to RNA (RNA viruses)
RNA to DNA (Retroviruses and Hep B)

4

What are NRTI's?

Nucleoside Reverse Transcriptase Inhibitor

5

NRTI's are analogues. What are the thymidine analogues?

Zidovudine, azidothymidine.

6

Give two examples of non-nucleotide reverse transcriptase inhibitors.

Efavirenz
Nevirapine

7

Give two examples of protease inhibitors.

Atazanavir. Darunavir.

8

Give an example of a fusion inhibitor

Enfuviritide

9

Give an example of an integrase inhibitor

Raltegravir

10

Give an example of a chemokine receptor antagonist (CCR5).

Maraviroc

11

What is HAART?

2 NRTIs + NNRTI
2 NRTIs + boosted PI

Switch of CD4 replication.

12

Which HIV mutation confers resistance to Lamivudine?

M184V

13

Which gene confers resistance to HIV?

CCR 5 delta 32

14

What is Aciclovir and what is it used for?

Nucleoside analogue.

HSV. VZV.

15

What is Ganciclovir used for?

Cytomegalovirus

16

What is Ribavirin used for?

Hep C and RSV

17

What are Interferons used for?

Hep C, Hep B

18

Name a cytosine analogue (NRTI).

Lamivudine.

19

Name two purine analogues (NRTIs).

Abacavir.
Tenofivir.

20

Which other protease inhibitor is used to boost the doses of other PIs?

Ritonavir.

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