Flashcards in 9 Diagnosis of autoimmune diseases Deck (17):
How good the test is in identifying people with the disease.
How good the test is at correctly defining people without the disease.
Define positive predictive value.
The proportion of people with a positive test result who have the disease.
Define negative predictive value.
The proportion of people with a negative test who do not have the disease.
7 non-specific markers of systemic inflammation.
ESP (plasma viscosity increases in infection).
CRP (liver produced, rises rapidly).
What are ANAs? How are they tested for?
Slide with antigens. Sample introduced. Second wave of fluorescently labelled antibodies matching ANA introduced.
If an ANA test is positive, which two tests come next?
Anti-ds DNA (crithidia luciliae assay, farr assay, ELISA).
Which two antibodies are commonly found in rheumatoid arthritis? Which is more specific?
Anti-CCP (ACPA). More specific. More severe disease - useful for prognosis.
What is the main target antigens of cytoplasmic ANCA?
What is the main target antigen of perinuclear ANCA?
Which three conditions are ANCA found in?
ANCA associated systemic vasculinities (AASV):
What use is ANCA in ANCA associated systematic vasculitides? (3).
Suggestive of diagnosis.
Return during -ve period may suggest flare.
Presence without clinical signs doesn't signal treatment need.
What antibodies are found in primary biliary sclerosis?
Which antibodies are found in autoimmune hepatitis?
Anti-smooth muscle and anti-liver/kidney/microsomal.
What course do autoantibodies take in Type 1 Diabetes Mellitus?
Initially increase with destruction of pancreas but disappear with progression and total destruction of beta islet cells.
Which four autoantibodies are found in type 1 DM?
islet cell antibodies
anti-GAD65 , anti-GAD67
anti-insulinoma antigen (IA-2)
insulin autoantibodies (IAAs)