Endocrine Control Female Reproduction 3 Flashcards
Summarize the gonadotropin releasing hormone regulation of gonadotropin secretion.
1
Q
What are some regulators of GnRH pulse frequency.
A
- dopamine
- serotonin
- opioids
- GABA
- glutamate
- NPY
- norepinephrine
- corticotrophin releasing hormone (CRH)
- leptin
2
Q
Describe the pulsatile nature of GnRH secretion.
A
-
Pulse generator
- endogenous pulse frequency in humans is 1 pulse/hour
- pulses necessary to maintain gonadotrope responsiveness to GnRH
- continuous GnRH delivery suppresses gonadotropin secretion
-
Puberty
- sleep entrained onset of pulsatile GnRH secretion
- CNS restraint of GnRH release before puberty
-
GnRH pulse frequency
- fast GnRH frequency increases LH
- slow GnRH pulse frequency selectively increases FSH release
