Pathology of Cervix, Vagina, and Vulva 6

Question 1

What is the clinical presentation of Paget’s disease manifested in the vulva?

Answer 1

• Vulvular lesion:
  
  • pruritic
  • crusted
  • erythematous

Question 2

What are the main histological findings of Paget’s disease in the vulva?

Answer 2

Infiltration of the squamous epithelium by neoplastic (but not necessarily malignant) glandular cells

Question 3

How does vulvar Paget’s disease differ from mammary Paget’s disease?

Answer 3

• Mammary - almost always associated with underlying breast carcinoma
• Vulvar - associated with benign neoplasms arising from sweat glands and hair follicles
  
  • some cases represent an underlying malignancy from the bladder, gynecologic tract, or colon