Pharmacology of Gonadal Hormones 5 Flashcards
Describe the actions and applications of agents that inhibit gonadal hormone synthesis or action.
1
Q
What are the common androgen receptor antagonists?
A
-
Flutamide
- treat hirsutism in females
- treat prostatic carcinoma and satyriasis in males
-
Spironolactone
- aldosterone antagonist
- can inhibit androgen receptors
2
Q
What are the common 5-alpha reductase (synthesis) inhibitors?
A
- Finasteride (vs. type 2)
- Dutasteride (vs. types 1 and 2)
- Used to treat benign prostatic hypertrophy
3
Q
What is gossypol?
A
- Cottonseed derivative
- Damages seminiferous tubules and decreases sperm
- Has been used as a male contraceptive for this “antigerminal” action
