Endocrine Control Female Reproduction 5 Flashcards
Explain the estradiol feedback on gonadotropin secretion.
1
Q
How do the sex hormones negatively and positively feed back on the pituitary?
A
- Negative feedback
- E2 and P slow GnRH pulse frequency
- Positive feedback
- E2 increases pituitary GnRH receptors and sensitivity to GnRH
2
Q
Why is E2 positive feedback necessary?
A
- necessary for LH surge and ovulation
- depends on amount and duration of E2 secretion
- LH surge stimulates ovulation of mature follicle and progesterone production by the corpus luteum
