Flashcards in 50S Inhibitors Deck (43):
What are the 3 clinically relevant Lincosamides?
What is the MOA of Lincosamides?
Bind to the 50S subunit of the ribosome and prevent exiting of the growing peptide chain.
Is the MOA of Lincosamides reversible or non-reversible? Bacteriostatic or bactericidal?
Reversible --> Bacteriostatic
What is the spectrum of the Lincosamides?
1. Gram (+) aerobes: Staph & Strep
2. Gram (+) anaerobes
3. Gram (-) aerobes: Campylobacter & Brachyspira
4. Gram (-) anaerobes: Bacteroides & Fusobacterium
5. Eukaryotes: Toxoplasma (Clindamycin)
Which is better with anaerobes, Clindamycin or Lincomycin?
Which is better with Staphylococcus, Clindamycin or Lincomycin?
What is Pirlimycin used against?
How is Pirlimycin administered?
When is Pirlimycin NOT to be used vs. mastitis?
NOT to be used vs. gram (-) bacilli
How do bacteria mount resistance to Lincosamides?
Via methylation of the ribosome, so the ribosome cannot produce proteins.
The methylation process through which Lincosamides mount resistance to bacteria confers resistance to what 3 drug classes?
Clindamycin causes ____ ____ due to inhibition of good intestinal microbes.
Which drug can be given in conjunction with Clindamycin to prevent pseudomembranous colitis?
What is virginiamycin a mixture of?
1. Virginamycin M (Group A)
2. Virginamycin S (Group B)
What is synercid a mixture of?
1. Dalfopristin (Group A)
2. Quinupristin (Group B)
What is the MOA for the Streptogramins?
Are Streptogramins bacteriostatic or bactericidal?
Bactericidal (2 drugs combined)
Group B Streptogramins share cross-resistance with which 2 antimicrobial classes?
Do Group A Streptogramins share cross-resistance with Group B?
Are Streptogramins water or fat soluble?
Are Streptogramins orally bioavailable?
No - poor oral bioavailability
How do Streptogramins have to be administered?
What is the spectrum of the Streptogramins?
Gram (+) aerobes and anaerobes
What are the 2 clinically relevant phenols?
What is the MOA of the phenols?
What is the spectrum of the Phenols (chloramphenicol and florfenicl)?
Very broad, including Rickettsia
Which 2 organisms are the Phenols resistant to?
How do bacteria mount resistance to the Phenols?
The bacteria modify the drug via acetylation
Which of the following has 2 targets for resistance: Chloramphenicol or Florfenicol?
Which of the following only has 1 target for resistance: Chloramphenicol or Florfenicol?
Resistance to which is less likely, Chloramphenicol or Florfenicol?
Which drug is the "broadest", Chloramphenicol or Florfenicol?
Why are the Phenols good against meningitis?
60% of the plasma concentration reaches the CSF
Which is more likely to cause aplastic anemia in a human, Chloramphenicol or Florfenicol?
How do the Phenols cause aplastic anemia?
Inhibit mitochondrial protein synthesis in erythropoeitic cells
What is Florfenicol used against in the cow?
Bovine respiratory disease
What is Florfenicol + NSAID?
What is the MOA of the pleuromutilins?
What are the 2 clinically relevant Pleuromutilins?
What is the spectrum of the Pleuromutilins?
What is the MOA of the oxazolidinones?
What is the spectrum of the Oxazolidinones?
Gram (+) aerobes and anaerobes