Polymyxins Flashcards Preview

Pharmacology Fall 2016 > Polymyxins > Flashcards

Flashcards in Polymyxins Deck (28):
1

What is the MOA of the polymyxins?

Bind to LPS on bacterial cell wall and disrupt the cell wall.

2

Are polymyxins bactericidal or bacteriostatic?

Bactericidal

3

Do polymyxins work on gram (+) and gram (-) bacteria?

Gram (-)

4

Is metronidazole bacteriostatic or bactericidal?

Bactericidal

5

What is the spectrum metronidazole?

1. Anaerobes

2. All protozoa

3. Anthelminthic

6

Which drug will never antagonize another drug?

Metronidazole

7

Which two toxicities are associated with metronidazole?

1. Carcinogenesis

2. Peripheral neuropathy

8

True or False: The peripheral neuropathy associated with metronidazole toxicity is reversible.

TRUE

9

What is the treatment for peripheral neuropathy associated with metronidazole toxicity?

Diazepam

10

For what is metronidazole used in food animals?

Metronidazole is BANNED in food animals

11

What are the MOA for the nitrofurans?

1. Same as metronidazole

2. Blocks Krebs cycle

3. Anti-70S

12

What is the spectrum of the nitrofurans?

Anaerobes and aerobes

13

What are the 2 toxicities associated with the nitrofurans?

1. Same as metronidazole (peripheral neuropathies & carcinogenesis)

2. Coagulopathies

3. Cardiotoxic

14

What are 2 clinical uses for the nitrofurans?

1. Topically for wounds

2. UTIs

15

Which of the following is banned in food animals: metronidazole or the nitrofurans?

BOTH

16

What is the MOA of Isoniazid?

1. Mycobacterium converts Isoniazid to a free radical

2. Free radical inhibits mycolic acid synthesis

3. Mycolic acid is necessary for cell wall synthesis

17

Is Isoniazid bactericidal or bacteriostatic?

Bactericidal

18

What is the spectrum of Isoniazid?

1. M.bovis

2. M. tuberculosis

19

What is the #1 choice vs. human tuberculosis?

Isoniazid

20

What are the 2 toxicities associated with Isoniazid?

1. Neurotoxicity

2. Hepatitis

21

Which 3 antibiotics are safe for use in guinea pigs?

1. Enrofloxacin

2. SMZ-TMP

3. Doxycycline

22

Integrons are transferred by ____.

Bacteriophage

23

Plasmids are transferred by ____.

Conjugation

24

What is the MOA of the bisphosphonates?

Inhibit DNA relaxase

25

Are the bisphosphonates bactericidal or bacteriostatic?

Bactericidal

26

Bisphosphonates will only kill bugs with both ____ and ____.

Integrons and plasmids

27

What is used to treat malignant hyperthermia in turkeys?

Reserpine

28

What is a long-term tranquilizer in horses?

Reserpine