Flashcards in Polymyxins Deck (28):
What is the MOA of the polymyxins?
Bind to LPS on bacterial cell wall and disrupt the cell wall.
Are polymyxins bactericidal or bacteriostatic?
Do polymyxins work on gram (+) and gram (-) bacteria?
Is metronidazole bacteriostatic or bactericidal?
What is the spectrum metronidazole?
2. All protozoa
Which drug will never antagonize another drug?
Which two toxicities are associated with metronidazole?
2. Peripheral neuropathy
True or False: The peripheral neuropathy associated with metronidazole toxicity is reversible.
What is the treatment for peripheral neuropathy associated with metronidazole toxicity?
For what is metronidazole used in food animals?
Metronidazole is BANNED in food animals
What are the MOA for the nitrofurans?
1. Same as metronidazole
2. Blocks Krebs cycle
What is the spectrum of the nitrofurans?
Anaerobes and aerobes
What are the 2 toxicities associated with the nitrofurans?
1. Same as metronidazole (peripheral neuropathies & carcinogenesis)
What are 2 clinical uses for the nitrofurans?
1. Topically for wounds
Which of the following is banned in food animals: metronidazole or the nitrofurans?
What is the MOA of Isoniazid?
1. Mycobacterium converts Isoniazid to a free radical
2. Free radical inhibits mycolic acid synthesis
3. Mycolic acid is necessary for cell wall synthesis
Is Isoniazid bactericidal or bacteriostatic?
What is the spectrum of Isoniazid?
2. M. tuberculosis
What is the #1 choice vs. human tuberculosis?
What are the 2 toxicities associated with Isoniazid?
Which 3 antibiotics are safe for use in guinea pigs?
Integrons are transferred by ____.
Plasmids are transferred by ____.
What is the MOA of the bisphosphonates?
Inhibit DNA relaxase
Are the bisphosphonates bactericidal or bacteriostatic?
Bisphosphonates will only kill bugs with both ____ and ____.
Integrons and plasmids
What is used to treat malignant hyperthermia in turkeys?