Flashcards in Aminoglycosides Deck (22):
True or False: Aminoglycosides are primarily oral drugs.
FALSE - aminoglycosides are pretty much only injectable drugs.
What is the MOA of the aminoglycosides?
Is the MOA of the aminoglycosides reversible or irreversible? Bacteriostatic or bactericidal?
Irreversible --> Bactericidal
Are Aminocyclitols bacteriostatic or bactericidal?
What is the spectrum of the aminoglycosides?
1. Gram (-) aerobes
2. Gram (+) cocci
Against which group of organisms are the aminoglycosides useless?
____ and ____ (Aminoglycosides) have activity vs. Pseudomonas.
Tobramycin and Amikacin
The combination of ____ and ____ WAS the gold standard vs. Pseudomonas.
Tobramycin and Ticarcillin
What is the MOST nephrotoxic aminoglycoside?
Which 3 aminoglycosides are most frequently associated with cochlear toxicity?
Which 3 aminoglycosides are most frequently associated with vestibulopathies?
Which is observed with aminocyclitols, cochlear toxicity or vestibulopathies?
Which is observed more in dogs, cochlear toxicity or vestibulopathies associated with aminoglycoside use?
Which is observed more in cats, cochlear toxicity or vestibulopathies associated with aminoglycoside use?
One side effect of Aminoglycosides is neuromuscular blockade. This is associated with the inhibition of what?
What are 2 treatment options for neuromuscular blockade associated with Aminoglycosides?
1. Calcium gluconate
Aminoglycosides are MOST incompatible with what?
With Aminoglycosides, which is more important: time above MIC or concentration above MIC?
Concentration above MIC
True or False: Aminoglycosides are polar compounds.
Aminoglycosides have a low or high Vd?
What is Paromomycin used against?