Aminoglycosides Flashcards Preview

Pharmacology Fall 2016 > Aminoglycosides > Flashcards

Flashcards in Aminoglycosides Deck (22):
1

True or False: Aminoglycosides are primarily oral drugs.

FALSE - aminoglycosides are pretty much only injectable drugs.

2

What is the MOA of the aminoglycosides?

30S inhibitors

3

Is the MOA of the aminoglycosides reversible or irreversible? Bacteriostatic or bactericidal?

Irreversible --> Bactericidal

4

Are Aminocyclitols bacteriostatic or bactericidal?

Bacteriostatic

5

What is the spectrum of the aminoglycosides?

1. Gram (-) aerobes

2. Gram (+) cocci

6

Against which group of organisms are the aminoglycosides useless?

Anaerobes

7

____ and ____ (Aminoglycosides) have activity vs. Pseudomonas.

Tobramycin and Amikacin

8

The combination of ____ and ____ WAS the gold standard vs. Pseudomonas.

Tobramycin and Ticarcillin

9

What is the MOST nephrotoxic aminoglycoside?

Neomycin

10

Which 3 aminoglycosides are most frequently associated with cochlear toxicity?

1. Kanamycin

2. Amikacin

3. Neomycin

11

Which 3 aminoglycosides are most frequently associated with vestibulopathies?

1. Streptomycin

2. Tobramycin

3. Gentamycin

12

Which is observed with aminocyclitols, cochlear toxicity or vestibulopathies?

NEITHER

13

Which is observed more in dogs, cochlear toxicity or vestibulopathies associated with aminoglycoside use?

Cochlear toxicity

14

Which is observed more in cats, cochlear toxicity or vestibulopathies associated with aminoglycoside use?

Vestibulopathies

15

One side effect of Aminoglycosides is neuromuscular blockade. This is associated with the inhibition of what?

nAch receptors

16

What are 2 treatment options for neuromuscular blockade associated with Aminoglycosides?

1. Calcium gluconate

2. Neostigmine

17

Aminoglycosides are MOST incompatible with what?

Beta-lactams

18

With Aminoglycosides, which is more important: time above MIC or concentration above MIC?

Concentration above MIC

19

True or False: Aminoglycosides are polar compounds.

TRUE

20

Aminoglycosides have a low or high Vd?

Low Vd

21

What is Paromomycin used against?

Cryptosporidium

22

According to the VFD, ____ is the only feed grade aminoglycoside.

Neomycin