Flashcards in Sulfonamides Deck (29):
What is the ratio of synergism between sulfonamides and benzylpyrimidines?
Sulfonamides inhibit which enzyme?
Dihydropteroate synthetase (DHPS)
Are the sulfonamides bactericidal or bacteriostatic?
Are the benzylpyrimidines bactericidal or bacteriostatic?
Benzylpyrimidines block which enzyme?
Dihydrofolate reductase (DHFR)
Together, are sulfonamides and benzylpyrimidines bacteriostatic or bactericidal?
What does the broad spectrum for the sulfonamides and benzylpyrimidines consist of?
1. Gram + (except enterococcus)
2. Gram - (except pseudomonas)
3. Protozoa - coccidia, cryptosporidia
Against which 3 microbial organisms are the sulfonamides and benzylpyrimidines useless?
If the MIC is ___ to the breakpoint, then the isolate is resistant.
> / _
If a bacteria is resistant to a sulfa, then it will be ____ to the sulfa + BP combination.
If a bacteria is susceptible to a sulfa, then it will be ____ to the sulfa + BP combination.
Sulfas and BPs are eliminated better in ____ urine.
____ concentrates x10 in the dog prostate and is a good choice against prostitis.
In terms of toxicities associated with sulfas and BPs, what is the #1 complaint and consideration?
Keratoconjunctivitis sicca (dry eye)
Sulfonamides and BPs are contraindicated in the doberman because they cause what?
Do not use sulfonamides or BPs on ____ ____, ____, in ____ ____, or with ____.
Do not use sulfonamides or BPs on RICKETTSIAL DISEASES, ABSCESSES, in MALE DOGS, or with TOLBUTAMIDE.
Which sulfonamide is NOT absorbed from the intestines?
What is the regulatory concern with sulfonamide/BP use?
NO extra-label use in dairy cattle
List the 4 Ionophores.
What is the mechanism of action of the Ionophores?
1. Insert into the cell wall
2. Bind Na, K, and H ions
3. Result in lethal pH drop
What is the spectrum of the Ionophores?
1. Gram (+) - bactericidal
2. Coccidia - bacteriostatic
What is the #1 toxicity concern with the Ionophores?
What are the 2 non-infectious uses of the Ionophores?
1. Prevent bloat
2. Growth-promotant in cattle
What are 5 indications for sulfonamide use?
1. Canine pyoderma
2. Canine and feline IBD
3. Coccidiosis in canine and feline
4. Bovine diarrhea
5. Bovine foot rot
What are 3 indications for ionophore use?
1. Prevent bloat
2. Coccidiosis in bovine, poultry, swine
3. Pulmonary edema
Sulfadimethoxine + ormethoprim
Canine and feline coccidiosis