Respiratory Pharmacology Flashcards Preview

Pharmacology Fall 2016 > Respiratory Pharmacology > Flashcards

Flashcards in Respiratory Pharmacology Deck (32):
1

Which 3 drugs are capable of B1 and B2 stimulation (Non-selective beta agonists)?

1. Epinephrine

2. Ephedrine

3. Isoproterenol

2

Which 3 drugs are solely capable of B2 stimulation (Selective beta-2 agonists)?

1. Terbutaline

2. Albuterol

3. Clenbuterol

3

What are the adverse effects of clenbuterol?

1. Muscle tremors

2. Tachycardia

3. Restlessness

4. Urticaria

4

What effect do beta 2 agonists have on the airways?

Bronchodilation

5

What effect do beta 2 agonists have on the uterus?

Inhibit uterine contraction

6

For what species is Clenbuterol approved in the U.S.?

Equine

7

What is Ventipulmin?

Clenbuterol

8

What type of effect do low levels of Clenbuterol have?

Beta 2 activity

9

What type of effect do high levels of Clenbuterol have?

Beta 1 activity in addition to beta 2 activity

10

How does Clenbuterol effect ciliary function?

Increases ciliary beat frequency

11

How does Clenbuterol effect uterine contractility ?

Decreases uterine contractions

12

According to the Association of Racing Commissioners International, Clenbuterol is a drug of which classification?

Classification 3

13

True or False: Clenbuterol does enhance racing performance in horses.

FALSE - there is no cardiopulmonary advantage in healthy horses.

14

What is the MOA of methylxanthine derivatives?

Inhibit phosphodiesterase

15

What are 2 methylxanthine derivatives?

1. Theophylline

2. Aminophylline

16

What is the adverse effect associated with beta agonists?

Vasoconstriction

17

What are the adverse effects associated with methylxanthine derivatives?

1. CNS excitation

2. GI upset

3. Diuresis

4. Tachycardia

18

What is the effect of methylxanthines on mast cells?

Inhibit mast cell degranulation

19

What is the effect of methylxanthines on the airways?

Bronchodilation

20

What is the effect of methylxanthines on the mucociliary escalator?

Increases mucociliary clearance

21

Which of the following can be used in small animals and horses, Theophylline or Aminophylline?

Theophylline

22

What are the adverse effects of theophylline small animals?

1. Nausea and vomiting

2. PU/PD/PP

3. Diarrhea

4. Restlessness

5. Increased gastric acidity

23

What are 3 anticholinergic modulators of the respiratory tract?

1. Atropine

2. Glycopyrrolate

3. Ipratropium

24

Which has the longer 1/2 life, atropine or glycopyrrolate?

Glycopyrrolate

25

What are 3 adverse effects of atropine?

1. Tachycardia

2. Ileus/GI stasis

3. Decreased mucociliary clearance

26

Which is a "better" bronchodilator, atropine or ipratropium?

Ipratropium

27

There are 2 classes of antitussives, what are they?

1. Peripheral

2. Central

28

What type of peripheral antitussive is potassium iodide?

Expectorants

29

How does potassium iodide work?

Increases fluidity of respiratory secretions

30

Which 2 bronchodilators are also peripheral anti-tussives?

1. Ephedrine

2. Theophylline

31

What are the 3 central narcotic anti-tussives?

1. Codeine

2. Hydrocodone

3. Butorphanol

32

What are the 2 adverse effects of codeine, hydrocodone, and butorphanol?

1. Sedation

2. Constipation