Flashcards in Respiratory Pharmacology Deck (32):
Which 3 drugs are capable of B1 and B2 stimulation (Non-selective beta agonists)?
Which 3 drugs are solely capable of B2 stimulation (Selective beta-2 agonists)?
What are the adverse effects of clenbuterol?
1. Muscle tremors
What effect do beta 2 agonists have on the airways?
What effect do beta 2 agonists have on the uterus?
Inhibit uterine contraction
For what species is Clenbuterol approved in the U.S.?
What is Ventipulmin?
What type of effect do low levels of Clenbuterol have?
Beta 2 activity
What type of effect do high levels of Clenbuterol have?
Beta 1 activity in addition to beta 2 activity
How does Clenbuterol effect ciliary function?
Increases ciliary beat frequency
How does Clenbuterol effect uterine contractility ?
Decreases uterine contractions
According to the Association of Racing Commissioners International, Clenbuterol is a drug of which classification?
True or False: Clenbuterol does enhance racing performance in horses.
FALSE - there is no cardiopulmonary advantage in healthy horses.
What is the MOA of methylxanthine derivatives?
What are 2 methylxanthine derivatives?
What is the adverse effect associated with beta agonists?
What are the adverse effects associated with methylxanthine derivatives?
1. CNS excitation
2. GI upset
What is the effect of methylxanthines on mast cells?
Inhibit mast cell degranulation
What is the effect of methylxanthines on the airways?
What is the effect of methylxanthines on the mucociliary escalator?
Increases mucociliary clearance
Which of the following can be used in small animals and horses, Theophylline or Aminophylline?
What are the adverse effects of theophylline small animals?
1. Nausea and vomiting
5. Increased gastric acidity
What are 3 anticholinergic modulators of the respiratory tract?
Which has the longer 1/2 life, atropine or glycopyrrolate?
What are 3 adverse effects of atropine?
2. Ileus/GI stasis
3. Decreased mucociliary clearance
Which is a "better" bronchodilator, atropine or ipratropium?
There are 2 classes of antitussives, what are they?
What type of peripheral antitussive is potassium iodide?
How does potassium iodide work?
Increases fluidity of respiratory secretions
Which 2 bronchodilators are also peripheral anti-tussives?
What are the 3 central narcotic anti-tussives?