9.24 Drugs in Foundations ILM Flashcards Preview

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Flashcards in 9.24 Drugs in Foundations ILM Deck (42):
1

prednisone is a type of _________. what is it used for? is it oral or topical?

steroid
pain relief and anti-inflammation
oral

2

clotrimazole:

class
mechanism of action

anti-fungal
inhibits fungal ergosterol synthesis

3

nystatin:

class
mechanism of action

anti-fungal
binds ergosterol, forms membrane pores
topical

4

ketorolac:

class
purpose
mechanism of action

NSAIDs
pain reliever and anti-inflammation
reversible COX inhibition (AA pathway, inhibiting COX and conversion to prostaglandins, etc.)

5

NSAIDs are used for 2 things:

pain relief and anti-inflammation

6

nafcillin:

class
mechanism of action

antibacterial (antibiotic)
ring that inhibits the cell wall formation in gram + bacteria

7

imiquimod:

class
mechanism of action
use

immune response modifier
stimulates innate immune cells via TLR, causing cytokine increase
can treat BCC, actinic keratoses, genital warts topically

8

terbinafene:

class
mechanism of action

anti-fungal
inhibits fungal enzyme for ergosterol syndrome
oral

9

aspirin:

class
purpose
mechanism of action

NSAID
pain and inflammation
irreversible COX inhibition

10

naproxen:

class
purpose
mechanism of action

NSAIDs
pain reliever and anti-inflammation
reversible COX inhibition (AA pathway, inhibiting COX and conversion to prostaglandins, etc.)

11

ketoconazole:

class
mechanism of action
topical or oral?

anti-fungal
inhibits fungal ergosterol synthesis
topical

12

griseofulvin:

class
mechanism of action

anti-fungal
interferes with microtubule function, disrupts mitosis
oral

13

gentamicin:

class
mechanism of action

antibacterial (antibiotics)
inhibit bacterial protein synthesis by inhibiting RNA translation into protein, binds to 30S ribosomal subunits

Gram -

14

cefazolin:

class
mechanism of action

antibacterial
inhibits cell wall biosynthesis

gram + bacteria

15

Steroids are used for 2 things:

pain relief and anti-inflammation

16

acyclovir:

class
mechanism of action

anti-viral
inhibits viral DNA polymerase

17

indomethacin:

class
purpose
mechanism of action

NSAIDs
pain reliever and anti-inflammation
reversible COX inhibition (AA pathway, inhibiting COX and conversion to prostaglandins, etc.)

18

celecoxib:

class
purpose
mechanism of action

NSAIDs
pain reliever and anti-inflammation
irreversible COX2 inhibition

19

triamcinolone is a type of ______. What is it used for? is it topical or oral?

steroid.
pain relief and anti-inflammation
topical

20

tetracycline:

class
mechanism of action

antibacterial (antibiotic)
inhibits RNA translation to protein - no protein synthesis

Gram - and gram +

21

isotretinoin:

class
mechanism of action

vitamin A analogue for acne
act at retinoic acid receptor (RAR), slows sebaceous gland proliferation and helps reduce inflammation

22

dexamethasone is a type of _______. what is the mechanism of action? is it oral or topical?

steroid
increase levels of lipocortin, inhibits phospholipase A2, decreasing inflammatory mediators
oral

23

sulfamethoxazole:

class
mechanism of action

antibacterial
blocks folic acid synthesis and thus blocks DNA synthesis

gram +

24

acetaminophen and paracetamol:

class
purpose
mechanism of action

no classification
pain reliever and antipyretic
mechanism unknown but does have some COX inhibition

25

tretinoin:

class
mechanism of action

vitamin A analogue for acne
act at retinoic acid receptor (RAR), slows sebaceous gland proliferation and helps reduce inflammation

26

ciproflaxin:

class
mechanism of action

antibacterial
inhibits DNA gyrase (a topoisomerase), inhibiting bacterial cell division

Gram - and gram +

27

penicillin:

class
mechanism of action

antibacterial (antibiotic)
inhibits the formation of the gram + bacterial cell wall

gram +

28

vancomycin:

class
mechanism of action

antibacterial
inhibition of gram + bacterial cell wall synthesis

29

permethrin:

class
mechanism of action
use

scabicides
insecticide - acts on arthropod Na+ channels and disrupts nerve and muscle function
topical treatment of scabies and lice

30

hydrocortisone is a type of ______. what is it used for? os it oral or topical?

steroid
pain relief and anti-inflammation
topical

31

metronidazole:

class
mechanism of action

antibacterial
damages DNA, inhibits nucleic acid synthesis

32

what is the mechanism of action of steroids?

increases levels of lipocortin, inhibits PLA2, decreasing inflammatory mediators since arachidonic acid can't be made. (AA pathway)

33

ibuprofen is an _______ (class). Why is it used? What is its mechanism of action?

NSAID
pain and inflammation
reversible COX inhibition (AA pathway, COX converts AA to prostaglandins, prostacyclins, etc.)

34

what is dexamethasone used for?

pain relief and anti-inflammation

35

dapsone:

class
mechanism of action

antibacterial
blocks folic acid synthesis and thus blocks DNA synthesis

36

amphotericin B:

class
mechanism of action

anti-fungal
binds ergosterol, forms membrane pores
oral

37

clindamycin:

class
mechanism of action

antibacterial (antibiotic)
disrupts protein synthesis

38

what are some side effects of NSAIDS?

GI irritation, GERD, GI ulcers
some cardiovascular dysfunctions (stroke, MI), decreased kidney function

39

what are some side effects of steroids?

prolonged use can lead to immunosuppression and Cushingoid (central obesity, moon face, hyperglycemia, osteoporosis).
Neuropsychiatric events

40

what medication family could cause the side effect of Cushingoid?

steroids

41

What are the side effects of isotretinoin?

potential for severe depression and suicide, teratogen, nose bleeds, dry skin, hair loss, GI disturbance, conjunctivitis, reduced night vision.

42

what are the side effects of tretinoin?

teratogen, dry skin, nosebleeds, hair loss, GI disturbance, conjunctivitis, reduced night vision