Cell Signaling ILM Flashcards Preview

Foundations Exam 3 > Cell Signaling ILM > Flashcards

Flashcards in Cell Signaling ILM Deck (12):
1

Target receptors are on the same cell. Signaling to itself (releases the extracellular signal and also has receptors for that signal)

autocrine signaling

2

Ligand on signaling cell binds to target cell receptors (not floating in space, displaying to the cell next door)

juxtacrine signaling

3

o Cytokines by T helper cells upregulate T helper cell activity
what type of signaling is this?

autocrine signaling

4


o Interactions between T lymphocytes and APCs
what type of signaling is this?

juxtacrine signaling

5

Target sites are on adjacent cells, the extracellular signaling molecule floats around and then finds the receptor. Rapid breakdown of the ligand helps prevent distant effects.

paracrine signaling

6

o Cytokines secreted by T helper cells upregulate activity of macrophages
what type of signaling is this?

paracrine signaling

7

Target sites are on distant cells (ex: hormones through blood stream). what kind of signaling is this?

endocrine signaling

8

Cytoplasmic domain (when activated by ligand-binding on extracellular side of receptor) bind a GTP binding protein (G protein). The G protein dissociates into active components that activate an effector molecule (ex – AC). This recruits second messengers (such as cAMP). What receptor type is this?

G-protein coupled receptor

9

when bound by the appropriate ligand, change conformation in such a way that a channel opens up across the membrane and allows ions to enter or leave the cell.

ligand gated ion channels

10

phosphorylated by a cytoplasmic kinase that interacts with the ligand-bound receptor OR self-activates by becoming phosphorylated when the receptor is bound by ligand. Phosphorylation of this receptor initiates cascade of kinase-mediated phosphorylation events that regulate gene expression.

kinase-linked receptors

11

Lipid-soluble signaling molecules can diffuse across the plasma membrane into the cell. They bind to receptors in the cytoplasm (commonly in nucleus). The ligand-bound receptor then functions to alter gene expression and protein synthesis.

intracellular receptors

12

remove phosphate groups

phosphotases