9.26 Pharmacogenomics Flashcards Preview

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Flashcards in 9.26 Pharmacogenomics Deck (13):
1

the study of the relationship between gene variants and drug effects

pharmacogenomics

2

differences in phenotypic differences when taking a drug may be attributed to ______ differences between individuals

genotipic

3

the most common type of variation in differences in genomics contributing to different reactions in drugs are _______________

single nucleotide polymorphisms (SNPs)

4

how can SNPs alter responses to drugs?

can increase or decrease:

absorption
metabolism
efficacy (through receptor interactions)
secretion

5

_____________ is a NMJ blocking drug that typically had a rapid onset and short duration.

succinylcholine

6

there are rare prolonged responses to succinylcholine due to _____ that changes an amino acid and results in atypical plasma cholinesterase, which _________ the drug.

SNPs
metabolizes

7

in people with SNPs in the plasma cholinesterase, people are _________ for longer when given ____________

paralyzed
succinylcholine

8

people with favism (get hemolytic anemia when eat fave beans) have a polymorphism in what protein?

glucose-6-phosphate dehydrogenase (G6PD)

9

people who have _____ polymorphism are vulnerable to drugs that are pro-oxidants (such as primaquine - a malaria drug) and can get ___________ _________ after taking those drugs.

G6PD
hemolytic anemia

10

individuals with _______ are either quick or slow metabolizers for drugs such as codeine. The enzyme also works on beta blockers and anti-hypertension drugs

CYP2D6

11

a mutation in __________ that causes rapid metabolism may induce morphine toxicity in children, since if given ______, that is metabolized to morphine.

CYP2D6
codeine

12

what enzyme is important in metabolizing drugs that are very toxic (such as azathioprine and mercaptopurine?)

thiopurine methyltransferase

13

when given a very toxic drug, polymorphisms in _________________ that make the enzyme deficient or nonfunctional, can have fatal side effects. Is this phase 1 or phase 2 metabolism?

thiopurine methyltransferase (TPMT)
phase 2 metabolism