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aabhemequick Flashcards

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1
Q

Vit K dependent Prothrombin group factors

A

2,7,9,10

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2
Q

Fibrinogen group, thrombin acts on, used up/not in serum

A

1,5,8,13

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3
Q

Intrinsic, factors…In..it also measures factors..drug it monitors…reagents…NV…phospholipoprotein inhibitor that prolongs aPTT,not corrected by mixing study…

A

8,9,11,12In aPTT it also measures 1,2,5,10heparinphospholipid+ Ca chloride30-36seclupus like anticoagulant

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4
Q

Common factors…measured in both…and….

A

1,2,5,10aPTT,PT

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5
Q

Factors in Contact grp, alternate activation of intrinsic

A

HMWK,PK11,12

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6
Q

extrinsic factors…In…also measures factors..drug names it monitors…reagent…NV….Uses…

A

TF/3, 71,2,5,20warfarin/coumadin thromboplastin10-13secUses INR/ISI

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7
Q

Prothrombinase complex is in common pathway and acts on prothrombin consist of these two factors and these two cofactors…

A

5a, 10acalcium+phospholipid

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8
Q

Protein C degrades…and…Protein…is cofactor that accelates inhibition

A

C degrades 5,8S is cofactor

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9
Q

Primary inhibitor of fibrinolytic system..Principal inhibitor of thrombin/10…

A

fibrinolytic: alpha2 antiplasmin-plasmin is main fibrinolysis agentInhibitor of thrombin/10: anthrombin 3

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10
Q

Labile coag factors…Severe liver disease coag factors..

A

5,81,5

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11
Q

Names:1234578910111213

A

1 fibrinogen2 prothrombin3 Tissue thromboplastin4 calicium5 labile7 stabile8 AHF A9 AHF B, christmas factor10 stuart prower11 AHF C12 Hageman13 fibrin stabilizing

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12
Q

7…9…two names10…12…

A

7: stabile9: ahf B, Christmas 10: stuart prower12: hageman

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13
Q

3 PLT disorders with increased BT and normal PLT ct…3 PLT disorderrs with increased BT and decreased PLT ct…

A

normal PLT:aspirin, vWD, Glanzmannsdecreased PLT:May Hegglin, BS, Wiscott

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14
Q

ITP, TTP, HUS, and DIC all have…PLT cts and …BT

A

decreased PLTs, increased BT

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15
Q

Two disorders with aggregation issues…-primary:-secondary:Two disorders with adhesion issues…

A

aggregation:-primary: Glanzmann only agg with ristocetin-secondary: Wiskott AldrichAdhesion:-vWB, BS

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16
Q

Most common inherited bleeding…2nd most common…Most common acquired inhibitor in hereditary def…Most common PLT disorder…

A

inherited bleeding:most common vWD,second Hemophiliaacquired inhibitor in hereditary def: 8Most common PLT disorder: aspirin

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17
Q

Disorder with no aggregation/flat line with anthing but ristocetin

A

Glansmann

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18
Q

Disorder with abnormal aggregation with most tests, except no aggregation/flat line with collagen

A

aspirin

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19
Q

Two disorders with no aggregation/flat line with ristocetin

A

VWD, BS

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20
Q

Order of hemotopoesis:

A

yolk sac, liver, spleen, BM

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21
Q

Embryonic hmg chains:-Gower 1:-Gower 2:-Portland:Newborn hmg and chains:Adult hmg and chains:

A

Embryonic hmg chains:-Gower 1: zeta, epilson-Gower 2: alpha, epilson-Portland: zeta, gammaNewborn hmg and chains: -F: alpha, gammaAdult hmg, chains, %:-A1: alpha, beta 97%-A2: alpha, delta 2%-F: alpha, gamma 1%Embroyonic has zeta, epilsonAdult has delta

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22
Q

Hmg electrophoresis:Cellulose acetate 8.4:slowest/cathode/- to fastest/anode+

A

Cellulose acetate 8.4:*slow(-) C, S, F, A fast(+)

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23
Q

Acronym for citrate agar 6.2 slowest/cathod to fastest anode…

A

-FASC+

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24
Q

cyanmethmg diluent…separate myoglobin from hmg with…sickle cell reagents, reducer/lyser…

A

cyanmethmg diluent…Drabkinsseparate myoglobin from hmg with…-ammoniun sulfatesickle cell reagents…-reducer: sodium dithionite-lyser: saponin

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25
Cell ct formula...WBC area of 1 square(usually of 4)...RBC/PLT of each tiny square...-RBC usually count 5-PLT usually count all 25 of middle, which equals total of...
cells x DF/ total square area (#sqsxarea square) x 0.1WBC 1 square is 1mmRBC/PLT 1 square is 0.04PLTs all 25 is 1mm(one WBC square)
26
3 things used to create scatterplots...1 not used
scatter, volume, conductivitynot fluorescence
27
Retic % cal...correct retic...RPI:
Retics/10retic % x HCT/45RPI: corrected/maturation time factor
28
WBC correction for NRBCs
WBC x 100/NRBC+100
29
4 things that falsely increase Hmg
lipemia, ictericincreased WBC, proteinAll cloud reading
30
Normal MCV, hypochromia due to
hyperglycemia
31
Decreased RBC, HCTIncreased MCV/MCHC due to
cold agg
32
Decreased RBC, Hmg, HCT...
anemia*if hmg high might be lipemia
33
Anemia is below...toddler:female:male:neonates:toddlers have the least, but close to adult femalesneonates have the most
Anemia is below...toddler: 12female: 13male: 15neonates: 19
34
Another name for reticulocyte, NVno nucleus, reticulum with supravital stain
polychromatophillic erythrocyte, 0.5-1.5%still has RNA, basophillic and orangw
35
2 names for NRBC, last nucleated red cell normally in BM, pyknotic nucleus
MetarubricyteOrthochromatic normoblast-more orange due to almost being erythrocyte
36
Alternate name for...1.)Rubriblast2.)Prorubricyte3.)Rubricyteblast before Pro, Pro before, meta after
Alternate name for...1.)Rubriblast: Pro-normoblast2.)Prorubricyte: Basophillic normoblast3.)Rubricyte: Polychormatophilic normoblastPro 1st, basophillic, polychromatophilic
37
Stages of WBC:-Stage with primary nonspecific granules-Stage with secondary specific granules, oval nucleus-Stage with kidney bean nucleus
-Stage with primary nonspecific granules:Promyelocyte-Stage with secondary specific granules, oval nucleus: Myelocyte-Stage with kidney bean nucleus: metamyelocyte
38
Life span...PLT...RBC...PLTs located, %...
PLT 8-11 daysRBC 120PLTs located, %-blood 70%-spleen 30%
39
MCH:calculations, NV
MCH: Hmg/RBC x 10 = 28-32 pg-mean cell hmg/rbc-wt
40
Normal values: female versus malesRBC:WBC:Hmg:HCT:
RBC: 4-6 million-females 4-5, males 5-6WBC: 4-11 thousandHmg: 12-18-females 13-15-males 14-18HCT: 35-54-females 35-49-males 40-54
41
WBC NV:Total WBC:-absolute is % x totalSegsLymphsMonosBandsEosBaso
total wbc: 4-11 thousandSegs: 45-70, mostLymphs: 20-40Monos: 3-10Bands: 0-5Eos: 0-3Baso: 0-2, least
42
Diluent for WBC/PLT cts
ammonium oxalate
43
2 normal cells seen in CSF
arachnoid and choroidboth very large clumps, pink/blue/purple
44
Normal cell seen in pleural fluid
mesothelialnucleated, large, clumped, more round than synovial
45
normal cell seen in synovial/joint
synovial cells, nucleated, not as uniform as pleural mesothelial
46
Newborn hmg, %
F 50-80A1 20A2 1
47
What 3 things increase WBC
NRBC, large platelets, Cryoglobin-Based off granularity, size
48
Schistocytes: affect on RBC, plts
RBC decreased because counted as plts
49
3 things decrease plt1 thing increase plt
Decrease plt: clumps, satellitosis, giant PLTsIncrease: schistocytes-counted as plts not rbcs
50
Plt ct with sodium citrate DF
1.1
51
PAS stains which blasts...Chronic or acute...
LymphoblastsAcute
52
conditions with target cells...1 not related to target...
Thallesemia, HmgpathiesIDA, post splenectomyLiver disease-Decreased hmgNot myelofibrosis
53
Diluent for wbc, plt...Reagent to diff myoglobin from hmg...
Diluent for wbc, plt...ammonium oxalate Reagent to diff myoglobin from hmg...Ammonium sulfate
54
Vit K dependent group called
Prothrombin group
55
Citrate agar: 6.2:slowest/cathod- to fastest/anode+
Citrate agar: 6.2:*slow(-) F,A,S,Cin some ways opposite of celluose acetate
56
MCV calc, NVRBC side nv
MCV: HCT/RBC x 10 = 80-100fL-In a volume of packed rbc, volume of rbc-volume: micro <80, macro>80-RBCs are 6-8 microns, <6 micro,>9macro
57
MCHC: calc, NV
MCHC: Hmg/HCT x 100= 32-36%-Hmg concentration in volume-color: hypo <32, hyper >36-percentage so smaller number on top->36 spherocytes
58
RDW: NV, indicates
RDW: 11-14.5, diff sizes/anisocytosis >15%
59
HCT: NV...Measures...
HCT: 35-54% packed cell volume
60
Hmg electrophoresis:nationality, migrates withD:E:G:
D: east indian, D-SE: Southeast asian, E-CG: Blacks, G-S
61
3 things that have leukopenia and 1 that has increased leukocytes
decreased:leukemia, viral, chemoincreased:leukemoid rxn
62
Myelocyte maturation from youngest to oldest
myeloblastpromyelocyte(pro b4 myelo)myelocytemetamyelocyte(meta after myelo)band
63
6 rbc inclusions
HJ bodiesPapemheimer bodies/siderocytes in PBBaso stippling/Shuffners dotsCabot ringHeinz bodies
64
Specific WBC that phagocytizes nucleoprotein in lupus erythematosus
NeutrophilLE cellcan also be macrophage
65
Characteristic findings:CLL:CML:ALL:AML:AMML:
CLL: smudge cells, sml BlymphsCML: Ph, basophilia, eosinophilia-decreased LAPALL: PAS+, MPO-, TdtAML: Auer rod, trans 8:21AMML: NASDA 3+, NaF 1+
66
what engulfs what...LE:Tart:Mott:
what engulfs what...LE: neutrophil,macro engults nucleoprotein-seen in lupusTart: mono/macrophage engulfs nuclearMott: plasma cell engulfs Ig, russel bodies
67
In reactive leukocytosis, absolute GRANULOCYTES are
>7.0
68
ALL: -which one has heterogenous?-which one has vacuolization/abundant cyto?-which one seen in kids/homogenous?L1L2L3
L1: homogenous, kidsL2: heterogenous, adultsL3: vacuolization, abundant cyto, homoL1/L2: L is younger than L2, start out homoL3: odd one with vacuoles
69
AML:-granules? least to most?-Auer rod, DIC?-Mono?-Erythroblast? Megakaryoblast?M0:M1:M2:M3:M4/5:M6:M7:
AML:M0: no granulesM1: granulesM2: few/trace granulesM3: intense granules, DIC, AuerM4/5: monoM6: erythroblastM7: megakaryoblast
70
Waldenstrom versus Multiple Myeloma:both have increased...and....WM Ig...MM Ig...MM also has...issues
both have extra plasma cells/lymphs and rouleauxWM Ig MMM IgG and bone issues
71
Condition with -elevated WBC/segs, increased -ESR/fibrinogen-decreased iron
Hodgkins, Reed Sternberg
72
Tears, giant bizarre plts, increased uric acid most ass with
myelofibrosis

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