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Flashcards in Abnormal Hemostasis Deck (16):
1

Thrombocytopemia

decreased platelet count

2

Thrombocytosis

benign increase

3

thrombocythemia

neoplastic increase

4

Heparin Induced Thrombocytopenia

thrombosis and thrombocytopenia
Heparin and PF4 complex and antibodies form against it

5

ITP
Immune thrombocytopenia

Anti-2b3a antibodies-splenic macrophage consumption of platelet-antibody complex. Commonly due to viral illness

Lab
-increase in megakaryocytes on bone marrow biopsy
-Increased bleeding time, decreased platelets

Treatment steroids, IV immunoglobulin

6

TTP
Thrombotic thrombocytopenic pupura

Inhibition or deficiency of ADAMTS 13 (vWF metalloprotease) --> degradation of vWF multimers

Pathogenesis: large vWF multimers--> increased platelet adhesion --> increased platelet aggregation and thrombosis

Labs: schistocytes, increased LDH

Symptoms: pentad of neurologic and renal symptoms, fever, thrombocytopenia, and microangiopathic hemolytic anemia

Treatment: plasmapheresis, steroids

7

HUS

hemolytic uremic syndrome

8

What are causes of decreased number of platelets?

1. alterations in bone marrow
2. hereditary thrombocytopenia
3.abnormal hematopoiesis
4. drug induced thrombocytopenia
5. dilutional

9

What are causes of increased number of platelets?

1. splenectomy
2. reactive thrombocytosis
3. autonomous thrombocytosis-cluster of platelets-bleeding may occur

10

What are causes of qualitative disorders of platelets?

1. disease induced platelet defects
2. drug induced platelet defects
3. diet induced platelet defects

11

What are some congenital disorders that result in bleeding?

1. Glanzmann's thrombasthenia
-autosomal recessive
-2b3a defect
-aggregation defect
-bleeding time increased

2. Bernard-Soulier disease
-autosomal recessive
-1b defect
-adhesion defect
-bleeding time increased

3. storage pool disease
-decrease dense granule content, no aggregation

4. other disorders
-purpura of unknown origin=gray platelet syndrome-lack of alpha granules

12

What are some acquired disorders of platelets?

1. metabolic disorders-uremia
2. myeloproliferative disorders-polycythemia vera

13

What are vascular disorders called?

nonthrombocytopenic purpuras
-easy bruising, bleeding from mucosa, purpura, vasculitis

14

What is ehler danlos syndrome?

congenital subendothelial disorder of hypermobile joints

15

Do hemophilias have an increased bleeding time? WHat about von willebrand's disease?

hemophilias-no
von willebrand's-yes

16

What is digested by plasmin in secondary fibrinolysis?

fibrin and fibrinogen