Flashcards in Neuromuscular Junction Disorders Deck (10)
Autoimmune disorder of the postsynaptic NMJ
-T cells with help of B cells destroy AchR
-normal architecture and folding of post synaptic junction is lost
Occurs at any age
What factor plays an important role in the etiology of MG?
-most often glandular enlargement or hyperplasia less often tumor or thymoma
Symptoms of MG?
weakness and fatigue of skeletal muscles
when doing non strenuous activity
-asymmetric weakness is common
-muscle reflex, sensation, higher cortical function normal
only visual symptoms
10-20% of patients
more than just occular
healthy newborns of myasthenic mothers may have MG symptoms for a few days until mothers antibodies are out
profound weakness may cause quadriplegia with the patient unable to speak swallow or breathe
Triggered by serious infection
What is the most specific test for MG?
serum AChR antibodies
Treatment of autoimmune MG
1. oral anticholinesterase drugs-pyridostigmine
-too high a dose will result in cholinergic crisis-weakness, sweatiness, salivation, diarrhea, excessive urination
3. maybe thymectomy?
1. IV immunoglobulin