Flashcards in Jaundice Deck (3)
CHildhood liver diseases tha tmay cuase neonatal jaundice?
1. biliary atresia
2. progressive familial intrahepatic cholestasis
3. alagille syndrome
4. alpha-1 antitrypsin deficiency
Primary biliary cirrhosis?
Destruction of intrahepatic bile ducts
progressive cholestatic liver disease
-middle aged women
-elevated alkaline phosphatase -elevation total bilirubin sign of advanced disease
Florrid duct lesion
-periductal inflammation with GRANULOMA formation and duct destruction
-portal tract with lymphocytes, plasma cells, eosinophils, macrophages and granulomas
-bile duct injury and bile ducts are infiltrated by lymphocytes
Treatment: ursodeoxycholic acid then transplant