Flashcards in Chronic Inflammation 8-5-15 Deck (13)
What is chronic inflammation characterized by?
-lymphocytes and macrophages
-proliferating blood vessels
-formation of connective tissue
What are the differences in onset, cellular infiltrate, tissue injury and fibrosis, local and systemic signs of acute vs chronic inflammation?
Onset: Fast(minutes or hours)
Cellular Infiltrate: Neutrophils
Tissue injury, fibrosis: mild and self-limited
Local and systemic signs: prominent
Cellular infiltrate: monocytes/macrophages and lymphocytes and plasma cells
Tissue injury, fibrosis: often severe and progressive
Local and systemic signs: less
What is the signature cell of chronic inflammation?
-M1 macrophage=inflammatory cytokines
What do chronic high levels of inflammatory cytokines cause?
1. Increase Hepatic production of defense proteins
2. Increased Hepcidin- sequester Fe
3.Increased growth factors for platelets and monocytes
M1 vs M2 macrophages
IFN-gamma-->phagocytosis (ROS NO lysosomal enzymes) and inflammation (Il1)
IL 13,4--> tissue repair fibrosis(growth factors, TGF b) and anti-inflammatory effects (IL 10 and TGF B)
What is granulomatous inflammation?
-microbial intracellular infection
-macrophage uptake of a poorly degradable foreign body
Sarcoidosis and IBD unknown etiology
WHat is the morphology of granulomatous inflammation?
1. central portion: necrotic debris
-caseous: commonly found in TB
2. Activated macrophages and multinucleated giant cells in periphery
3. cuff of T-cells, CD3/CD4 postive
4. entire granuloma is rimmed by proliferating fibroblasts
During inflammation what do hepatocytes produce more of?
2. Complement Components (C3)
What happens to albumin synthesis during inflammation?
-rough correlation between decrease and duration of inflammatory response
What does the increased production of hepcidin lead to?
What do growth factors stimulate the marrow to produce during inflammation?
1. increased leucocyte production
2. increased platelet production
(leukocytosis and thrombocytosis can be present)
What does C-Reactive Protein (CRP) measure? What stimulates it?
CRP is stimulated by inflammation and tightly linked to IL 6 levels
-when normal excludes significant inflammation being present
-obesity false elevation of CRP