Glycosaminoglycans
Deficiency in alpha-1 iduronidase
dermatin and heparin sulfate elevated
IDUA gene
autosomal recessive
Laronidase therapy
ocular clouding-ground glass
chronic rhinitis
otitis media
CARDIOVASCULAR most common cause of death
hydrocephalus
progressive developmental delay
coarse facial features
flat face
prominent forehead
large head
thick lips, large tongue
skeletal deformities
-more prominent as child ages
