Flashcards in Acute leukemias Deck (55):
What is the median age of onset for AML? Gender?
What is the 5 year survival rate of acute leukemia?
What is the median age of onset for ALL?
What is the 5 year survival rate for ALL?
What are the genetic abnormalities that predispose pts to leukemia?
What are the three malignant conditions that are associated with acute leukemia?
Marrow failure syndromes
What are the chemical exposure that can lead to MDS?
What chemo agents predispose to leukemia?
Who gets CML?
65 yo males
What is the incidence of CLL?
4/100000, but way underreported
What is the 5 year survival rate of CML? CLL?
CML = 60%
CLL = 80%
True or false: CLL does not usually need to be treated
What are the SSx of acute leukemia? (4)
What is sweet syndrome?
red/violaceous tender nodules and plaques (dermatosis) d/t PMN sequestration
What are the eye findings with acute leukemia?
What are the CNS findings with acute leukemia?
What are the oropharyngeal findings with acute leukemia?
Is organomegaly common in acute leukemia?
What is the classification system for AML?
What is M3 leukemia?
acute progranulocytic leukemia
Auer rods = ?
(fused lysosomes and PMN granules with enzymes and crystalline inclusions)
What is leukemia cutis?
skin manifestations of leukemia
What are the mouth findings of leukemia?
What are the drugs that can cause gingival hyperplasia?
What is the recommended site of bone marrow extraction?
What are the risk factors for bone marrow exams?
What is William Damesheck's insight?
Had to give a big dose of chemo to ablate the bone marrow
What is the 7+3 induction therapy for AML?
Anthracycline x 3 days + cytarabine x7 days
What are the drugs used to consolidation therapy?
High dose cytarabine, then bone marrow transplant
What is APL? What is the treatment?
Can there be a philadelphia chromosome with AML?
AML induction support is what?
Transfused pRBCs (irradiate)
What is the risk of transfusion with AML during induction support?
What are the growth factors that can be used with AML induction support?
GM-CSF or G-CSF
What food should be avoided in induction support for AML?
no raw berries or veggies grown in dirt
What is the problem with tumor lysis in treating leukemia? How do you treat this?
Allopurinol and alkanization of urine
What happens with 1st trimester prego with new diagnosis of leukemia?
Child will not survive
What is APL genetic cause?
t(15;17) resulting in the fusion of PML/RAR-alpha
What is the treatment for APL?
All trans-retinoic acid with 7+3 induction
What is the prognosis for APL?
What is the major complication with APL?
What is the median age of ALL?
What is the prognosis for ALL if >35 yo
What are the chromosomal translocation for ALL?
What is the treatment for ALL induction?
Ara-c with methotrexate
What is the treatment for ALL in adults?
Bone marrow transplant
What are the drugs used for ALL maintenance therapy in adults?
Is there a maintenance therapy in AML?
What are the ssx of CML?
What did Jane Rowley do?
Argued that specific gene translocations cause specific diseases
What is the translocation associated with CML?
BCR-ABL promotes Y kinase to promote cell growth
What are the three risk factors for CML?
What is the treatment for CML?
What is the chemo treatment for CML?