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Flashcards in Lymphoma II Deck (59):
1

What are the ages of Hodgkin's lymphoma?

20-30, then >50

2

Who gets hodgkin's lymphoma?

Male caucasians

3

What is the survival rate of Hodgkin's disease?

85%

4

What are the two associated infectious agents with Hodgkin's lymphoma?

EBV and HIV

5

What are the ssx of Hodgkin's disease?

fevers/chills/night sweats/weight loss
Pruritis
EtOH induced pain in lymph nodes

6

What are the common areas of lymphadenopathy of Hodgkin's disease?

70% cervical
60% mediastinal

7

What is the major difference in lymphadenopathy between Hodgkin's and NHL?

Contiguous in HL

8

True or false: unilateral bone marrow biopsy for HL is sufficient

True

9

What is stage I HD?

1 nodal region or lymph node

10

What is stage II HD?

2 or more nodal regions on the same side of diaphragm

11

What is stage III HD?

Both sides of the diaphragm

12

What is stage IV HD?

>1 extranodal sites

13

What is a Reed Sternberg cell?

B cell origin with multinuclei (owl eyes)

14

What are the two CD markers for HD?

CD15 and CD30

15

What are the markers for adverse prognostic factor for HD?

Albumin 15
Hb

16

What is the prognosis for HL disease?

Very good

17

What are the treatments for HD?

Chemo + XRT. One alone if low grade, both if advanced

18

Which is more common: NHL or HL?

NHL

19

Who is usually affected by NHL?

Adult, white men

20

What are the two types of NHL?

B cell (85%) and T cell (15%)

21

What is the 5 year survival for NHL?

67%

22

What are the infectious agents that are implicated with NHL?

EBV
HTLV-1
HCV
HHV8
H.pylori

23

What are the occupations/exposures of NHL? (3)

Agriculture
Benzene exposure
Prior Chemo/radiation

24

What are the ssx of NHL?

b-sx, but more symptoms if aggressive

25

When is an LP indicated for NHL?

testicular, nasopharyngeal involvement

26

What is the translocation for follicular lymphoma? Oncogene?

t(14;18)
bcl-2

27

What is the translocation for SLL? Oncogene?

t(14;19)
bcl3

28

What is the translocation for mantle cell lymphoma? Oncogene?

t(11;14)
bcl1

29

What is the translocation for burkitt's lymphoma? Oncogene?

t(8;14)
myc

30

What is the translocation for DLCL? Oncogene?

t(3;14)
bcl6

31

What are the two very aggressive NHLs?

Burkitt's
Any T cell

32

What is diffuse large cell lymphomas?

Rapidly enlarging mass with extranodal sites

33

What is the overall cure rate of diffuse large cell lymphoma?

45%

34

What are the prognostic factors for diffuse large cell NHL?

LDH elevated
Age >60
>1 extranodal site

35

What is the treatment for diffuse large cell NHL?

Chemo + rituxan

NOT surgical

36

What is the chemo treatment for DLCL?

Cyclophosphamide
Adriamycin
Vincristine
Prednisone

37

What is the MOA of rituximab?

Anti CD20 ab that targets DLCL

38

What is small lymphocytic lymphoma? (ssx)

Indolent CA with enlarging LN over months to years

Usually asymptomatic

39

Who gets SLL?

Late to middle aged

40

What is the prognosis for SLL?

Incurable

41

What is Richter's transformation?

about 35% of follicular lymphomas will transform into DLCL at 10 years of disease

42

What is the treatment for indolent lymphoma, SLL?

Curative radiation therapy if early stages

Palliative radiation + chemo if advanced stages

43

What are the three very aggressive NHLs?

Lymphoblastic lymphoma
Burkitt's lymphoma
Any T cell lymphoma

44

Who usually gets very aggressive NHL?

Peds and young adults

45

What is the prognosis for very aggressive NHLs?

Curable, but very aggressive

46

Who gets a stem cell/BM transplant for aggressive lymphoma? What type of transplant is this?

DLCL, follicular, and very aggressive lymphomas

Autologous stem cells

47

What is MALT lymphoma? Where is this usually found?

Mucosa associated lymphoid tissue lymphoma

GI tract, lungs, breasts

48

What is the treatment for MALT d/t h.pylori?

usual treatment for H.pylori

Chemo if not spontaneous remission after

49

What are the three HIV associated lymphoma?

DLCL
Burkitt's
CNS lymphoma

50

Where are HIV associated lymphoma found?

Anus/rectum
Soft tissues

51

What is the major prognosis factor for HIV associated lymphoma?

Low CD4 counts

52

Who gets CLL?

Older pts with immunodeficiency conditions

53

Which type of lymphocyte is associated with CLL?

B cells

54

Where is CLL found in the body?

Always in bone marrow and peripheral blood

55

What are the ssx of CLL?

Asymptomatic to infectious symptoms

Lymphadenopathy/splenomegaly

56

What are the labs like i CLL?

Leukocytosis
Low IgG, IgA and IgM

57

What are the CD markers for CLL?

CD5
CD20
CD23

58

What is stage 0 - 4 of CLL?

0 = lymphocytosis
1 = Lymphadenopathy
2 = Splenomegaly
3 = Anemia
4 = thrombocytopenia

59

What is the prognosis for CLL? Treatment?

Not curable, but treat with chemo when high stage or very symptomatic