Flashcards in Thrombocytopenia Deck (52):
What is thrombocytopenia?
What are the three underlying causes of thrombocytopenia?
What is the normal ranges of platelets?
How big are platelets relative to RBCs?
What is the cell that produces platelets?
What is the chemical that determines the rate and amount of platelet production?
What are the receptors on platelets that binds to vWF, and serves as an intracellular signal?
Stocking distribution of paresthesias with low pancytopenia =?
Where are platelets sequestered, generally?
What are the viral causes of thrombocytopenia? (2)
Pts with sickle cell disease are susceptible to what viral infections?
What are the two common causes of thrombocytopenia that fall under the medication/drug category?
What are the three causes of marrow replacement that causes thrombocytopenia?
If the MCV is greater than 115, what is the disease?
What are the two platelet dysfunctions with pernicious anemia?
Diminished platelet aggregation
Decreased release of ATP, ADP
Elevated methylmalonic acid levels = ?
What are the tests to diagnose pernicious anemia? (3)
What is the treatment for pernicious anemia?
SQ B12 replacement (can't give PO d/t lack of IF)
Why is an EGD indicated for pernicious anemia?
What is pseudothrombocytopenia?
Platelet aggregation or clumping in the test tube (in vitro)
What is the solution to pseudothrombocytopenia?
Use a blue top tube with heparinized blood
thrombocytopenia with o/w normal CBC + bleeding from gums + mucocutaneous petechial rash = ?
ITP (immune thrombocytopenia purpura)
What is ITP?
Accelerated destruction of platelets by immune destruction
How do you diagnose ITP?
Diagnosis of exclusion
What are the results of a bone marrow biopsy with ITP?
Normal to increased number of megakaryocytes
The incidence of ITP increases or decreases with age
What are the antiplatelet abs that are involved in ITP targeted against?
IgG to GPII/IIIa receptor
True or false: transfusions to pts with ITP still result in destruction of platelets
What are the usual symptoms of ITP?
What is the first line of drug treatment for ITP? Second? Third?
What is the last resort for ITP treatment?
What is antiphospholipid antibody syndrome?
Abs to GPIIa/IIIb
Is HUS/TTP immune mediated?
HELLP syndrome is indicated by what? (3)
HIT is caused by what?
Immune mediated destruction of platelets after exposure to heparin
What do abs in HIT attach to?
heparin and PF4 complex
What type of heparin has a lower risk of HIT?
Low molecular weight heparin
What happens to HIT pts when they are left untreated?
How do you manage HIT?
True or false: you can administer heparin in pts who have had HIT before?
True, but needs to be more than 6 months
Jaundice everywhere but the sclera is what?
Thrombocytopenia d/t to sequestration generally results in what PE findings?
What are the four causes of splenic sequestration?
1/ Hereditary spherocytosis
3. Hairy cell leukemia
4. MALT lymphoma
True or false: DM is a common cause of liver cirrhosis
What are the three components of thrombocytopenia?
1. Careful H&P
2. Lab eval
3. Bone marrow biopsy
What are the three things to look for in a PE of thrombocytopenia?
What are the two diseases that contraindicate platelet transfusion? Why?
May accelerate platelet destruction
For every unit of blood, how much increase in platelets should you expect?
What are the three things that should be a part of a PE for pts with thromboytopenia?
When is a bone marrow biopsy indicated?
2 or more cell lines affected
What is the more common cause of underproduction thrombocytopenia?