Flashcards in Pathology of Lymphoma Deck (76):
What are the two major distinction between lymphomas?
B cell origin
T cell origin
What are the malignancies that come from the germinal center of a lymph node?
Large cell lymphoma
What are the lymphomas that arise from the mantle zone of lymph nodes?
Naive B cell
Mantle cell lymphoma
What are the lymphomas that arise from the marginal zone of the lymph node?
Memory B cell
Marginal zone lymphoma
What are the clinical symptoms of follicular lymphoma? (3)
What are the two cells that compose follicle germinal center lymphomas?
Centroblasts and centrocytes
What is the characteristic of low grade follicular lymphoma? High grade?
Low = mostly centrocyte
High = greater than 15 centroblasts/hpf
What are the gross histological findings of follicular lymphoma?
High grade infiltration of lymph nodes s/t there is no discernable structure
What is the difference between centroblasts and centrocytes?
Centrocytes are smaller with more condensed nuclei
Centroblasts have a lot more cytoplasm
What are the four CD markers for follicular lymphoma?
What are the two markers that are absent in follicular lymphoma?
What are the markers for T cells? (3)
What is the function of Bcl-2?
Who gets mantle cell lymphoma?
50-60 year old males
What are the symptoms of mantle cell lymphoma?
What organs are affected in mantle cell lymphoma?
What are the characteristic lab findings with mantle cell lymphoma?
If there is small bowel involvement with mantle cell lymphoma, what is this called?
What are the cell markers for mantle cell lymphoma?
What are the negative markers for mantle cell lymphoma?
What is cyclin D1?
Anti Apoptotic molecule that is characteristic of mantle cell lymphomas
What is endemic burkitt lymphoma?
EBV viral infection in young africans
What is sporadic burkitt lymphoma?
Worldwide childhood infection
True or false: only the sporadic type of Burkitt lymphoma has CNS involvement
What is the presentation for endemic burkitt lymphoma?
Jaw enlargement, ovaries, kidney involvement
What are the symptoms of sporadic Burkitt lymphoma?
Abdominal masses in the ileo-cecal region
What are the symptoms of Immunodeficient Burkitt lymphoma?
Nodal localization and involvement of BM is frequent
"Starry sky pattern" on histology = ?
What are the histological findings of Burkitt's lymphoma?
Diffuse **monomorphic** infiltrate of intermediate sized round to slightly irregular lymphoid cells with multiple peripherally place nucleoli
What does tigible mean?
What are the tingible bodies in histological samples of Burkitt's lymphoma?
Macrophages in germinal centers
What are the CD markers for Burkitt's lymphoma? What is distinguishes it from follicular lymphoma?
NEGATIVE for bcl-2
CD10+CD19+CD20 = ?
CD19 + CD20 + CD5 + Cyclin D1 = ?
Mantle cell lymphoma
What is the prognosis for Burkitt lymphoma?
Responds well to therapy (90% cure with low stage)
True or false: aggressive Burkitt lymphoma is a medical emergency
What is the viral cause of adult T cell leukemia/lymphoma?
HTLV-1 (HUman T-cell Leukemia virus type 1)
Where is adult T cell leukemia/lymphoma endemic?
True or false: T cell leukemia/lymphoma is only found in adults
What is the latency period of HTLV1?
What is the common presentation of adult T cell lymphoma? (3 physical findings + 2 lab findings)
What are the histological features of adult T cell leukemia/lymphoma?
Immature = smooth, even chromatin
Mature = multilobed nuclei
What type of T cell is found in adult T cell lymphoma?
What is the virus that is found in Adult T cell leukemia?
Flower cells = ?
Adult T cell leukemia
What is the prognosis for adult T cell leukemia/lymphoma?
Rapidly progressive, death within 1 year despite chemo
What is the new therapy for Adult T cell lymphoma?
True or false: adult T cell leukemia/lymphoma with primarily skin involvement is more aggressive
What organ is always involved in mycosis fungoides/Sezary syndrome?
What is the cell type that is involved in mycosis fungoides/Sezary syndrome?
Cd4+ T cells
What is the prognosis for mycosis fungoides/Sezary syndrome?
What are the histological characteristics of mycosis fungoides/Sezary syndrome?
Folded nuclear membrane
What are the three stages of mycosis fungoides/sezary syndrome?
Plaque (with epidermal involvement)
Tumor phase (dermis involvement)
What are the very late stages of mycosis fungoides/sezary syndrome?
Sezary syndrome presents with 2 simultaneous manifestations. What are they?
Generalized exfoliative erythroderma
Leukemia+Generalized exfoliative erythroderma = ?
What are the two major immature T cell lymphoid neoplasms/lymphomas?
T lymphoblastic leukemia
Anaplastic large T cell lymphoma
What are the two clinical manifestations of T lymphoblastic leukemia/lymphoma?
85% as lymphoma with anterior mediastinal lymph nodes
15% as leukemia ( T-ALL)
What is the presentation of T cell ALL?
Abrupt onset with depression of normal marrow, fatigue, infx, bleeding etc.
What are the CNS ssx of T cell ALL?
nerve palsy d/t meningeal spread
What are the histological characteristics of T-ALL?
Sheets of blasts in lymph node, soft tissue, or bone marrow
What are the cell markers for T-ALL? (4)
TdT cell marker = ?
CD34 + TdT + CD1a = ?
Which has a worse prognosis: B-ALL or T-ALL?
What are the three factors that determine the prognosis of T-ALL?
1. Under 2 yo
2. Philadelphia chr
3. WBC >100
Who usually gets anaplastic large cell lymphoma?
What are the cell markers for Anaplastic large T cell lymphoma
Is anaplastic large cell lymphoma hodgkin's or non-hodgkin's?
What sites are involved in anaplastic large cell lymphoma?
Which age group has ALK-1 positive anaplastic large cell lymphoma? Negative? Which has a good prognosis, and which has a poor prognosis?
Positive = children/young adults, good prognosis
Negative = edler adults, bad prognosis
What are the histological characteristics of anaplastic large cell lymphoma?
pleomorphic with characteristic "hallmark" cells
What are the four characteristics of hallmark cells in large cell lymphoma?
1. medium size
2. Abundant cytoplasm
3. Kidney shaped nuclei
4. Paranuclear eosinophilic region
What is large granular lymphocytic leukemia?
T cell/NK cell type
Associated with RA