Adrenoceptor Agonists and Antagonists (M1)

Question 1

What is the parent compound of sympathomimetic drugs?

Answer 1

phenylethylamine

Question 2

Where do catecholamines have -OH groups? 1. What are they inactivated by? 2

Answer 2

1. 3 and 4 positions on benzene ring

2. COMT in gut and liver

Question 3

What are the mixed-acting adrenoceptor agonists?

Answer 3

1. dopamine
2. ephedrine
3. Pseudoephedrine (decongestant)`

Question 4

What is a tumor of the adrenal medulla or sympathetic ganglion cells called?

Answer 4

Phenochromocytoma

Question 5

What determines individual differences in the amount something is metabolized?

Answer 5

Cytochrome P450

Question 6

What are the metabolic and endocrine effects of bet antagonists?

Answer 6

1. dec sym stimulation of lipolysis
2. dec glycogenolysis
3. hypoglycemia
4. inc VLDL
5. dec HDL

Question 7

What do beta blockers do for hyperthyroidism?

Answer 7

1. block adrenoceptors

2. inhibit conversion of thyroxine to triiodothyronine