Skeletal Muscle Relaxants (M3)

Question 1

What is the substance used on arrows to kill animals by skeletal muscle paralysis? 1. What is the active compound in this? 2

Answer 1

1. curare

2. D-tubocurarine

Question 2

What are the peptides of a nicotinic receptor in skeletal muscles?

Answer 2

2 alpha, 1 gamma, 1 delta

Question 3

Do quaternary nitrogens have good or bad lipid solubility?

Answer 3

poor

Question 4

What is the only way neuromuscular blocking drugs can be administered?

Answer 4

parenteral only

Question 5

What are the two phases of depolarizing relaxant drugs?

Answer 5

1. depolarizing

2. desensitizing

Question 6

What is the last skeletal muscle to be paralyzed?

Answer 6

diaphragm

Question 7

Do inhaled anesthetics inhibit or enhance effect for muscle relaxants?

Answer 7

enhance

Question 8

Do antibiotics inhibit or enhance the effect for muscle relaxants?

Answer 8

enhance

Question 9

Do severe burns inhibit or enhance the effect for muscle relaxants?

Answer 9

inhibit

Question 10

Which drugs reverse nondepolarizing neuromuscular blockades (what is their mechanism)?

Answer 10

1. Neostigmine, pyridostigmine, edrophonium (Cholinesterase inhibitors)
2. Sugammadex (binds steroidal neuromuscular blockers)

Question 11

What are causes of muscle spasticity?

Answer 11

1. spinal injury
2. cerebral palsy
3. multiple sclerosis
4. stroke

Question 12

What are the drugs to treat acute local muscle pain? 1. What level do they act on? 2

Answer 12

1. cyclobenzaprine, carisoprodol, chlorphenesin, chlorzoxazone, metaxalone, methocarbamol, and orphenadrine
2. brain stem