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II. Pharmacology > Antivirals (M3) > Flashcards

Antivirals (M3) Flashcards

1
Q

What are the main structures of a virus?

A
  1. central core of nucleic acid
  2. outer protein coat (capsid)
  3. envelope
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2
Q

What are the types of DNA viruses?

A
  1. parvo virus
  2. papovavirus
  3. adenovirus
  4. herpes virus
  5. pox virus
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3
Q

What are the types of RNA viruses?

A
  1. Picorna virus
  2. reoviruses
  3. arboviruses
  4. togoviruses
  5. orthomyxo viruses
  6. paramyxo viruses
  7. rhabdo viruses
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4
Q

What are combinations of lipids, proteins and carbohydrates that help make up a virus?

A

envelopes

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5
Q

What is a nucleocapsid + envelope called?

A

virion

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6
Q

What are the ways viruses leave a host cell?

A
  1. rupturing cell membrane

2. slowly budding out of surface of cell membrane

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7
Q

Are antivirals virustatic, virucidal, or both?

A

virustatic

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8
Q

Where does the herpes virus move through in the body on initial acquisition?

A
  1. dorsal root ganglia

2. trigeminal ganglia

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9
Q

What is the treatment for stromal HSV? 1. Endothelial HSV? 2

A
  1. topical steroids and oral antiviral

2. topical steroid and oral antiviral

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10
Q

What are the types of infections associated with CMV?

A
  1. retinitis
  2. colitis
  3. esophagitis
  4. CNS disease
  5. pneumonitis
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11
Q

What disease has cotton wool spots, infiltrates and hemorrhages on the retina?

A

CMV reitinitis

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12
Q

What is a nucleoside + a phosphate called?

A

nucleotide

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13
Q

What can be added to DNA and RNA chains as decoys to stop the chain from growing?

A

nucleoside analogs replacing nucleotides

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14
Q

What type of cells does HIV destroy?

A

CD4

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15
Q

What are the lab tests to confirm HIV?

A
  1. CD4 count
  2. viral load
  3. drug resistance of HIV strain to anti-HIV meds
  4. tests for complications (other diseases, damage)
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16
Q

What is a family of enveloped viruses that replicate in a host cell through the process of reverse transcription called?

A

retroviridae

17
Q

What is the combination therapy to treat HIV/AIDS called? 1. How many agents are used? 2

A
  1. HAART (highly active antiretroviral therapy)

2. at least three

18
Q

What is the absence of detectable viremia 24 weeks after completion of therapy called?

A

sustained viral response (SVR)

19
Q

Which influenzas cause pandemics?

A

Influenza A

II. Pharmacology (43 decks)

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