Drug Endings (F)

Question 1

What is the mechanism of drugs with the ending -crolimus? 1. What are they used for? 2

Answer 1

1. Binds to cytoplasmic peptidylprolyl isomerases and FKBK to inhibit calcineurin
2. Organ transplantation and GVH diseases

Question 2

What is the mechanism of drugs with the ending -rolimus? 1. What are they used for? 2

Answer 2

1. blocks mTOR to inhibit T cell proliferation

2. transplants, GVH disease, uveoretinitis

Question 3

What is the mechanism of drugs with the ending -lidomide? 1. What are they used for? 2

Answer 3

1. inhibit angiogenesis and TNF-aloha

2. GVH disease, leprosy, Lupus multiple myeloma

Question 4

What is the mechanism of drugs with the ending -flunomide? 1. What are they used for? 2

Answer 4

1. pyrimidine synthesis inhibitors

2. RA, transplants, autoimmune diseases, MS

Question 5

What is the mechanism of drugs with the suffix -anakin-? 1. What are they used for? 2

Answer 5

1. IL-1 receptor antagonist

2. inflammatory diseases

Question 6

What is the mechanism of drugs with the ending -prazole? 1. What are they used for? 2

Answer 6

1. irreversible blockade of H+/K+-ATPase pump

2. acid-peptic diseases

Question 7

What is the mechanism of drugs with the ending -tidine? 1. What are they used for? 2

Answer 7

1. competitive inhibition of parietal cell H2 receptor

2. GERD, peptic ulcer disease, bleeding prevention

Question 8

What is the mechanism of drugs with the ending -setron? 1. What are they used for? 2

Answer 8

1. 5-HT3 antagonist to inhibit colonic motility and smooth muscle activity
2. IBS

Question 9

What is the mechanism of drugs with the ending -aprepitant? 1. What are they used for? 2

Answer 9

1. NK1-receptor blocker in CNS

2. emesis (vomiting)

Question 10

What is the mechanism of drugs with the ending -salazine? 1. What are they used for? 2

Answer 10

1. inhibit NK cells, mucosal lymphocytes and macrophages

2. Crohn’s disease and ulcerative colitis

Question 11

What is the mechanism of drugs with the ending -estrol? 1. What are they used for? 2

Answer 11

1. estrogen agonist

2. estrogen deficiency, hypogonadism, postmenstrual hormonal therapy

Question 12

What is the mechanism of drugs with the ending -estrel? 1. What are they used for? 2

Answer 12

1. bind to progesterone receptors

2. hormone replacement therapy, hormonal contraception, dysmenorrhea, endometriosis

Question 13

What is the mechanism of drugs with the ending -sterone? 1. What are they used for? 2

Answer 13

1. testosterone agonist

2. growthstimulation, androgen replacement therapy, hypoptuitarism

Question 14

What is the mechanism of drugs with the ending -relin? 1. What are they used for? 2

Answer 14

1. GnRH analogs

2. advanced prostatic carcinoma

Question 15

What is the mechanism of drugs with the ending -asteride? 1. What are they used for? 2

Answer 15

1. inhibit conversion of steroid precursors to androgens

2. reduce prostate size