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II. Pharmacology > Drug Endings (M3) > Flashcards

Drug Endings (M3) Flashcards

1
Q

What class are the drugs with the ending -curium or -curonium in? 1. What are they used for? 2

A
  1. competitive antagonist at nACh receptors

2. Relaxation for surgical procedures (muscle relaxants)

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2
Q

What class are the drugs with the ending -giline in? 1. What are they used for? 2

A
  1. monoamine oxidase (MAO) inhibitor

2. Parkinson’s Disease

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3
Q

What class are the drugs with the ending -capone in? 1. What are they used for? 2

A
  1. COMT inhibitor

2. Parkinson’s Disease

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4
Q

What is the mechanism of drugs with the ending -azine? 1. What are they used for? 2

A
  1. D2 receptor blockades (phenothiazines)

2. Schizophrenia, bipolar disorder

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5
Q

What is the mechanism of drugs with the ending -zapine and -idone? 1. What are they used for? 2

A
  1. 5-HT(2A) receptor blockers

2. Schizophrenia, bipolar disorder, agitation Alzheimer’s and Parkinson’s

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6
Q

What is the mechanism of drugs with the ending -xetine and -lopram? 1. What are they used for? 2

A
  1. Serotonin reuptake inhibitor

2. major depression, anxiety, OCD, PTSD

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7
Q

What is the mechanism of drugs with the ending -lafaxine and -nacipran? 1. What are they used for? 2

A
  1. Blockers of NET and SERT

2. major depression, chronic pain, fibromyalgia

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8
Q

What is the mechanism of drugs with the ending -pramine and -triptyline? 1. What are they used for? 2

A
  1. Blockers of NET and SERT (TCAs)

2. major depression, chronic pain, incontinence, OCD

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9
Q

What is the mechanism of drugs with the ending -zodone? 1. What are they used for? 2

A
  1. inhibition of 5-HT(2A) receptor

2. major depression, sedation and hypnosis

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10
Q

What is the mechanism of drugs with the ending -morphine? 1. What are they used for? 2

A
  1. strong u-receptor agonist

2. severe pain, anesthesia, pulmonary edema

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11
Q

What is the mechanism of drugs with the ending -codone and -codeine? 1. What are they used for? 2

A
  1. u-receptor agonist

2. mild-moderate pain, cough

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12
Q

What is the mechanism of drugs with the beginning nal-? 1. What are they used for? 2

A
  1. u,d,k-receptor antagonists

2. opioid overdose, constipation, drug addict maintenance, weight loss

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13
Q

What is the mechanism of drugs with the ending -adol? 1. What are they used for? 2

A
  1. u-receptor agonist and NET/SERT inhibitor

2. moderate pain

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14
Q

What is the mechanism of drugs with the ending -zepam? 1. What are they used for? 2

A
  1. positive modulators of GABA

2. delirium tremens

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15
Q

What is the mechanism of drugs with the ending -cillin? 1. What are they used for? 2

A
  1. prevent bacterial cell wall synthesis by binding to and inhibiting transpeptidases
  2. bacterial infections
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16
Q

What is the mechanism of drugs with the beginning cef- or ceph-? 1. What are they used for? 2

A
  1. prevent bacterial cell wall synthesis by binding to and inhibiting transpeptidases
  2. bacterial infections
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17
Q

What is the mechanism of drugs with the ending -penem? 1. What are they used for? 2

A
  1. prevent bacterial cell wall synthesis by binding to and inhibiting transpeptidases
  2. bacterial infections
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18
Q

What is the mechanism of drugs with the ending -actam? 1. What are they used for? 2

A
  1. inhibit bacterial beta lactamases

2. bacterial infections

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19
Q

What is the mechanism of drugs with the ending -cycline? 1. What are they used for? 2

A
  1. prevents bacterial protein synthesis by binding to 30s ribosomal subunit, blocking tRNA attachment
  2. bacterial infections
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20
Q

What is the mechanism of drugs with the ending -thromycin? 1. What are they used for? 2

A
  1. prevents bacterial protein synthesis by binding to 50s ribosomal subunit, blocking translocation from A site to P site
  2. bacterial infections
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21
Q

What is the mechanism of drugs with the ending -pristin? 1. What are they used for? 2

A
  1. prevents bacterial protein synthesis by binding to 50s ribosomal subunit
  2. gram + bacteria and MRSA
22
Q

What is the mechanism of drugs with the ending -zolid? 1. What are they used for? 2

A
  1. prevents bacterial protein synthesis by binding to 23s ribosomal RNA of 50s ribosomal subunit
  2. gram + bacteria
23
Q

What is the mechanism of drugs with the beginning sulfa-? 1. What are they used for? 2

A
  1. folate antagonists that blocks purine production and nucleic acid production by inhibiting dihydropteroate
  2. bacterial infections
24
Q

What is the mechanism of drugs with the middle -metho-? 1. What are they used for? 2

A
  1. inhibits dihydrofolate reductase by competitive inhibition
25
Q

What is the mechanism of drugs with the ending -floxacin? 1. What are they used for? 2

A
  1. binds to topoisomerase II (DNA gyrase)

2. bacterial infections

26
Q

What is the mechanism of drugs with the ending -azole? 1. What are they used for? 2

A
  1. blocks fungal P450 enzymes and interferes with ergosterol synthesis, increasing membrane permeability
  2. antifungal
27
Q

What is the mechanism of drugs with the ending -fungin? 1. What are they used for? 2

A
  1. blocks beta-glucan synthase

2. antifungal

28
Q

What is the mechanism of drugs with the ending -fine? 1. What are they used for? 2

A
  1. inhibits epoxidation of sequalene in fungi

2. antifungal

29
Q

What is the mechanism of drugs with the ending -cyclovir or -ciclovir? 1. What are they used for? 2

A
  1. inhibits DNA polymerase

2. antiviral

30
Q

What is the mechanism of drugs with the ending -vudine? 1. What are they used for? 2

A
  1. competitive inhibition of HIV1 reverse transcriptase

2. HIV/AIDS and HBV

31
Q

What is the mechanism of drugs with the ending -virdine? 1. What are they used for? 2

A
  1. bind to HIV1 reverse transcriptase and inhibits DNA polymerase activity
  2. HIV/AIDS
32
Q

What is the mechanism of drugs with the ending -navir? 1. What are they used for? 2

A
  1. prevent post-translational cleavage of Gag-Pol polyprotein by HIV protease
  2. HIV/AIDS
33
Q

What is the mechanism of drugs with the ending -tegravir? 1. What are they used for? 2

A
  1. binds to integrase, inhibiting strand transfer

2. HIV/AIDS

34
Q

What is the mechanism of drugs with the ending -previr? 1. What are they used for? 2

A
  1. protease inhibitor, so inhibits synthesis

2. HCV

35
Q

What is the mechanism of drugs with the ending -mivir? 1. What are they used for? 2

A
  1. neuraminidase inhibitor, clumping newly released virons to each other
  2. influenza A and B viruses
36
Q

What is the mechanism of drugs with the ending -mantadine? 1. What are they used for? 2

A
  1. block M2 proton ion channel of virus; inhibit uncoating of viral RNA in host
  2. influenza
37
Q

What is the mechanism of drugs with the ending -quine? 1. What are they used for? 2

A
  1. prevent conversion of heme into hemozoin

2. malaria

38
Q

What are drugs with the beginning arte- used for?

A

malaria

39
Q

What is the mechanism of drugs with the ending -fantrine? 1. What are they used for? 2

A
  1. against erythrocytic stage

2. malaria

40
Q

What is the mechanism of drugs with the ending -phenol? 1. What are they used for? 2

A
  1. disrupt cell walls and membranes

2. decontamination of bacteria, fungi, viruses

41
Q

What is the mechanism of drugs with the ending -mustine? 1. What are they used for? 2

A
  1. form DNA crosslinks to inhibit DNA synthesis and function

2. cancers

42
Q

What is the mechanism of drugs with the ending -carbazine? 1. What are they used for? 2

A
  1. methylates DNA and inhibits DNA synthesis and function

2. Hodgkins and non-Hodgkins lymphoma, melanoma, brain tumors, soft tissue sarcoma

43
Q

What is the mechanism of drugs with the ending -platin? 1. What are they used for? 2

A
  1. forms DNA cross-links, inhibiting DNA synthesis and function
  2. cancers
44
Q

What is the mechanism of drugs with the ending -trexate? 1. What are they used for? 2

A
  1. inhibits DHFR, TS, and purine nucleotide synthesis

2. cancers

45
Q

What is the mechanism of drugs with the ending -abine? 1. What are they used for? 2

A
  1. inhibits DNA synthesis and repair by inhibiting DNA polymerase A and B; inhibits ribonucleotide reductase
  2. cancers
46
Q

What is the mechanism of drugs with the ending -rubicin? 1. What are they used for? 2

A
  1. oxygen free radicals bind to DNA causing single and double strand DNA breaks; inhibits topoisomerase II
  2. AML, ALL, CML in blast crisis
47
Q

What is the mechanism of drugs with the ending -taxel? 1. What are they used for? 2

A
  1. inhibits mitosis by binding to microtubules

2. cnacers

48
Q

What is the mechanism of drugs with the ending -tecan? 1. What are they used for? 2

A
  1. inhibits topoisomerase I

2. cancers

49
Q

What is the mechanism of drugs with the beginning vin-? 1. What are they used for? 2

A
  1. inhibits mitosis (at metaphase) by inhibiting tubular polymerization; disrupts microtubule assembly
  2. cancers
50
Q

What is the mechanism of drugs with the ending -tinib? 1. What are they used for? 2

A
  1. inhibits tyrosine kinase or growth factor tyrosine kinase (erlotinib)
  2. CML, non-small cell lung cancer, pancreatic cancer

II. Pharmacology (43 decks)

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