Asthma Drugs (M2)

Question 1

What cells experience hyperplasia during asthma?

Answer 1

1. bronchial vasculature
2. smooth muscle
3. secretory glands
4. goblet cells

Question 2

What layer is thickened during asthma?

Answer 2

lamina reticularis

Question 3

When do asthma symptoms occur?

Answer 3

1. exposure to allergens or air pollutants
2. exercise
3. after viral upper respiratory infection
4. night

Question 4

What are the two models for the pathogenesis of asthma?

Answer 4

1. allergen challenge model

2. bronchial hyper-reactivity model

Question 5

What is the allergen challenge model mediated by?

Answer 5

IgE

Question 6

What are the mediators during the early asthmatic response?

Answer 6

1. histamine
2. tryptase
3. Leukotrienes C4 and D4
4. Prostaglandin D2

Question 7

What cytokines do Th2 lymphocytes produce?

Answer 7

IL-5, 9, 13

Question 8

What do the cytokines produced by Th2 activate?

Answer 8

eosinophils

Question 9

What type of asthma agent is normally used for mild asthma?

Answer 9

inhalation of bronchodilator

Question 10

What type of asthma agent is normally used for severe asthma?

Answer 10

inhaled corticosteroid

Question 11

What is the normal management plan to treat acute asthma?

Answer 11

1. inhaled beta2 receptor agonist
2. treat with oxygen
3. aerosolized albuterol
4. systemic treatment with prednisone or methylprednisolone