Chemo Drugs that Act on the Cell Wall and Membrane (M3)

Question 1

What is the 3-membered nitrogen group that determines the mechanism of action found in penicillinc and cephalosporins?

Answer 1

Beta lactam

Question 2

What are penicillins susceptible to inactivation by?

Answer 2

1. amidases

2. lactamases

Question 3

What is penicillin metabolized by (and what does each result in)?

Answer 3

1. bacterial amidase (aminopenicillanic acid)

2. gastric acid (penicilloic acid)

Question 4

What are the possible mechanisms to become resistant to penicillins?

Answer 4

1. inactivation of antibiotic by beta-lactamase
2. modification of target PDPs
3. impaired penetration of drug to target PDPs
4. antibiotic efflux

Question 5

What does MRSA stand for?

Answer 5

methicillin resistant staph aureus