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Agent Used In Anemias & Hematopoietic Growth Factors Flashcards

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0
Q

Oral iron preperations

A

Ferrous gluconate

Ferrous fumarate

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1
Q

Iron

A 
Ferrous sulfate
Ferrous gluconate
Ferrous fumarate
Iron dextran
Iron sucrose complex
Sodium ferric gluconate complex
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2
Q

Ferrous gluconate

Ferrous fumarate

A

Oral iron preperations

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3
Q

Iron dextran
Iron sucrose complex
Sodium ferric gluconate complex

A

Parenteral preparation; can cause pain, hypersensitivity reactions

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4
Q

Parenteral preparation; can cause pain, hypersensitivity reactions

A

Iron dextran
Iron sucrose complex
Sodium ferric gluconate complex

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5
Q

Ferrous sulfate

Mechanism of action

A

Required for biosynthesis of heme and heme-containing proteins, including hemoglobin and myoglobin

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6
Q

Ferrous sulfate

Mechanism of action

A

Required for biosynthesis of heme and heme-containing proteins, including hemoglobin and myoglobin

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7
Q

Ferrous sulfate

Effects

A

Adequate supplies required for normal heme synthesis

Deficiency results in inadequate heme production

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8
Q

Adequate supplies required for normal heme synthesis

Deficiency results in inadequate heme production

A

Ferrous sulfate

Effects

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9
Q

Ferrous sulfate

Clinical applications

A

Iron deficiency, which manifests as microcytic anemia

Oral preparation

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10
Q

Ferrous sulfate

Effects

A

Ferrous sulfate

Clinical applications

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11
Q

Ferrous sulfate

Toxicity

A

Acute overdose results in necrotizing gastroenteritis, abdominal pain, bloody diarrhea, shock, lethargy, and dyspnea
Chronic iron overload results in hemochromatosis, with damage to the heart, liver, pancreas, and other organs
Orgen failure and death can ensue

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12
Q

Acute overdose results in necrotizing gastroenteritis, abdominal pain, bloody diarrhea, shock, lethargy, and dyspnea
Chronic iron overload results in hemochromatosis, with damage to the heart, liver, pancreas, and other organs
Orgen failure and death can ensue

A

Ferrous sulfate

Toxicity

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13
Q

Iron chelators

A

Deferoxamine

Deferasirox

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14
Q

Deferoxamine

A

Iron chelator

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15
Q

Deferasirox

A

Iron chelator

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16
Q

Deferasirox

Usage

A

Orally administered iron chelator for treatment of hemochromatosis

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17
Q

Orally administered iron chelator for treatment of hemochromatosis

A

Deferasirox

Usage

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18
Q

Deferoxamine

Mechanism of action

A

Chelates excess iron

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19
Q

Chelates excess iron

A

Deferoxamine

Mechanism of action

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20
Q

Deferoxamine

Effects

A

Reduces toxicity associated with acute or chronic iron overload

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21
Q

Reduces toxicity associated with acute or chronic iron overload

A

Deferoxamine

Effects

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22
Q

Deferoxamine

Clinical applications

Study These Flashcards
A

Acute iron poisoning inherited or acquired hemochromatosis

23
Q

Acute iron poisoning inherited or acquired hemochromatosis

Study These Flashcards
A

Deferoxamine

Clinical applications

24
Deferoxamine Toxicity
Rapid IV administration may cause hypotension | Neurotoxicity and incresed susceptibility to certain infection have occurred with long-term use
25
Rapid IV administration may cause hypotension | Neurotoxicity and incresed susceptibility to certain infection have occurred with long-term use
Deferoxamine Toxicity
26
Vitamin B12
Cyanocobalamin | Hydroxocobalamin
27
Hydroxocobalamin
Vitamin B12
28
Cyanocobalamin
Vitamin B12
29
Cyanocobalamin (vitamin B12) Hydroxocobalamin (vitamin B12) Mechanism of action
Cofactor required for essential enzymatic reaction that form tetrahydrofolate, coverts homocysteine to methionine, and metabolize L-methylmalonyl-CoA
30
Cofactor required for essential enzymatic reaction that form tetrahydrofolate, coverts homocysteine to methionine, and metabolize L-methylmalonyl-CoA
Cyanocobalamin (vitamin B12) Hydroxocobalamin (vitamin B12) Mechanism of action
31
Cyanocobalamin (vitamin B12) Hydroxocobalamin (vitamin B12) Effects
Adequate supplies required for amino acid and fatty acid metabolism, and DNA synthesis
32
Adequate supplies required for amino acid and fatty acid metabolism, and DNA synthesis
Cyanocobalamin (vitamin B12) Hydroxocobalamin (vitamin B12) Effects
33
Cyanocobalamin (vitamin B12) Hydroxocobalamin (vitamin B12) Clinical applications
Vitamin B12 deficiency, which manifests as megaloblastic anemia and is the basis for pernicious anemia
34
Vitamin B12 deficiency, which manifests as megaloblastic anemia and is the basis for pernicious anemia
Cyanocobalamin (vitamin B12) Hydroxocobalamin (vitamin B12) Clinical applications
35
Cyanocobalamin (vitamin B12) Hydroxocobalamin (vitamin B12) Toxicity
No toxicity associated with excess
36
No toxicity associated with excess
Cyanocobalamin (vitamin B12) Hydroxocobalamin (vitamin B12) Toxicity
37
Reference range of vitamin B12
180-914 ng/L or 150-900 pg/mL
38
180-914 ng/L or 150-900 pg/mL
Reference range of vitamin B12
39
Folic acid
Folacin (pteroylglutamic acid)
40
Folacin (pteroylglutamic acid)
Folic acid
41
Folacin (pteroylglutamic acid) Mechanism of action
Precursor of an essential donor for methyl groups used for synthesis of amino acids, purines, and deoxynucleotide
42
Precursor of an essential donor for methyl groups used for synthesis of amino acids, purines, and deoxynucleotide
Folacin (pteroylglutamic acid) Mechanism of action
43
Folacin (pteroylglutamic acid) Effects
Adequate supplies required for essential biochemical reactions involving amino acid metabolism, and purine and DNA synthesis
44
Adequate supplies required for essential biochemical reactions involving amino acid metabolism, and purine and DNA synthesis
Folacin (pteroylglutamic acid) Effects
45
Erythrocyte-stimulating agents
Epoetin alfa Darbepoetin alfa Methoxy polyethylene glycol-epoetin beta
46
Darbepoetin alfa
Erythrocyte-stimulating agent
47
Methoxy polyethylene glycol-epoetin beta
Erythrocyte-stimulating agent
48
Epoetin alfa
Erythrocyte-stimulating agent
49
Epoetin alfa Mechanism of action
Agonist of erythropoietin receptors expressed by red cell progenitors
50
Agonist of erythropoietin receptors expressed by red cell progenitors
Epoetin alfa Mechanism of action
51
Epoetin alfa Effects
Stimulates erythroid proliferation and differentiation, and induces the release of reticulocytes from bone marrow
52
Stimulates erythroid proliferation and differentiation, and induces the release of reticulocytes from bone marrow
Epoetin alfa Effects
53
Epoetin alfa Clinical applications
Anemia, especially anemia associated with chronic renal failure, HIV infection, cancer and prematurity Prevention of the need for transfusion in patients undergoing certain types of elective surgery
54
Anemia, especially anemia associated with chronic renal failure, HIV infection, cancer and prematurity Prevention of the need for transfusion in patients undergoing certain types of elective surgery
Epoetin alfa Clinical applications
55
Epoetin alfa Toxicity
Hypertension, thrombotic complications, and very rarely, pure red cell aplasia
56
Hypertension, thrombotic complications, and very rarely, pure red cell aplasia
Epoetin alfa Toxicity

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