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Flashcards in Drugs Used In Disorders Of Coagulation Deck (47):
0

Indirect thrombin inhibitors

Unfractionated heparin (UFH)
Low-molecular-weight heparin (LMWH)
Fondaparinux

1

Unfractionated heparin (UFH)

Indirect thrombin inhibitor

2

Low-molecular-weight heparin (LMWH)

Indirect thrombin inhibitor

3

Fondaparinux

Indirect thrombin inhibitor

4

Antithrombin lll

Endogenous anticoagulant

5

Antithrombin lll

Actions

Antithrombin inhibits clotting factor proteases, especially thrombin (lla), lXa, and Xa, by forming equimolar stable complexes with them. In the absence of heparin, these reactions are slow; in presence of heparin, they are accelerated 1000-fold.

6

inhibits clotting factor proteases, especially thrombin (lla), lXa, and Xa, by forming equimolar stable complexes with them. In the absence of heparin, these reactions are slow; in presence of heparin, they are accelerated 1000-fold.

Antithrombin lll

Actions

7

LMW heparins

Enoxaparin
Dalteparin
Tinzaparin

8

Enoxaparin

LMW heparin

9

Dalteparin

LMW heparin

10

Tinzaparin

LMW heparin

11

Protamine sulfate

Usage

Antagonist of heparin

12

Antagonist of heparin

Protamine sulfate

Usage

13

Oral direct factor Xa inhibitors

Rivaroxaban
Apixaban

14

Apixaban

Oral direct factor Xa inhibitor

15

Rivaroxaban

Oral direct factor Xa inhibitor

16

Rivaroxaban
Apixaban

Actions

Inhibit factor Xa, in the final common pathway of clotting

17

Inhibit factor Xa, in the final common pathway of clotting

Rivaroxaban
Apixaban

Actions

18

Direct thrombin inhibitors (DTIs)

Hirudin
Bivalirudin
Argatroban
Melagatran
Dabigatran etexilate mesylate

19

Parenteral direct thrombin inhibitors (DTIs)

Hirudin
Lepirudin
Bivalirudin
Argatronan

20

Hirudin

Parenteral direct thrombin inhibitor (DTI)

21

Lepirudin

Parenteral direct thrombin inhibitor (DTI)

22

Bivalirudin

Parenteral direct thrombin inhibitor (DTI)

23

Argatronan

Parenteral direct thrombin inhibitor (DTI)

24

Oral direct thrombin inhibitor (DTI

Dabigatran etexilate mesylate

25

Dabigatran etexilate mesylate

Oral direct thrombin inhibitor (DTI

26

Fibrinolytic drugs

Streptokinase
Urokinase
Alteplase
Reteplase
Tenecteplace

27

Streptokinase

Fibrinolytic drug

28

Urokinase

Fibrinolytic drug

29

Alteplase

Fibrinolytic drug (Manufactured human t-PA)

30

Tenecteplace

Fibrinolytic drug (Manufactured human t-PA)

31

Reteplase

Fibrinolytic drug (Manufactured human t-PA)

32

Manufactured human t-PA

Alteplase
Reteplase
Tenecteplace

33

Fibrolytic drugs

Indications

Pulmonary embolism with hemodynamic instability
Severe deep venous thrombus
Ascending thrombophlebitis
(Acute myocardial infarction, depends on circumstances)

34

Pulmonary embolism with hemodynamic instability
Severe deep venous thrombus
Ascending thrombophlebitis
(Acute myocardial infarction, depends on circumstances)

Fibrolytic drugs

Indications

35

Antiplatelet agents

Aspirin
Ticlopidine
Clopidogrel
Prasugrel
Abciximab
Eptifibatide
Tirofiban
Dipyridamole
Cilostazol

36

Aspirin

Antiplatelet agent (cyclooxygenase inhibitor)

37

Ticlopidine

Antiplatelet agent (ADP pathway inhibitor)

38

Clopidogrel

Antiplatelet agent (ADP pathway inhibitor)

39

Prasugrel

Antiplatelet agent (ADP pathway inhibitor)

40

Abciximab

Antiplatelet agent (glycoprotein llb/llla inhibitor)

41

Eptifibatide

Antiplatelet agent (glycoprotein llb/llla inhibitor)

42

Tirofiban

Antiplatelet agent (glycoprotein llb/llla inhibitor)

43

Antiplatelet agents (glycoprotein llb/llla inhibitors)

Abciximab
Eptifibatide
Tirofiban

44

Antiplatelet agents (ADP pathway inhibitors)

Ticlopidine
Clopidogrel
Prasugrel

45

Aminocaproic acid

Clinically useful inhibitor of fibrinolysis

46

Clinically useful inhibitor of fibrinolysis

Aminocaproic acid