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Flashcards in Diuretics Deck (64)
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Carbonic anhydrase inhibitors

Acetazolamide
Brinzolamide
Dorszolamide

1

Acetazolamide

Carbonic anhydrase inhibitor

2

Brinzolamide

Carbonic anhydrase inhibitor
(Topical for glaucoma)

3

Dorszolamide

Carbonic anhydrase inhibitor
(Topical for glaucoma)

4

Carbonic anhydrase inhibitor
Mechanism of action

Inhibition of the enzyme prevents dehydration of H2CO3 and hydration of CO2 in the proximal convoluted tubule

5

Inhibition of the enzyme prevents dehydration of H2CO3 and hydration of CO2 in the proximal convoluted tubule

Carbonic anhydrase inhibitor
Mechanism of action

6

Acetazolamide
Mechanism of action

Inhibition of the enzyme prevents dehydration of H2CO3 and hydration of CO2 in the proximal convoluted tubule

7

Carbonic anhydrase inhibitor
Effects

-Reduces reabsorbtion of HCO3- , causing self-limited diuresis
-hyperchloremic metabolic acidosis reduces body ph, reduces intraocular pressure

8

Carbonic anhydrase inhibitor
Clinical applications

Glaucoma, moutain sickness, edema with alkalosis

9

Glaucoma, moutain sickness, edema with alkalosis

Carbonic anhydrase inhibitor
Clinical applications

10

Loop diuretics

Furosemide
Bumetanide
Torsemide
Ethacrynic acid

11

Furosemide

Loop diuretic (sulfonamide)

12

Bumetanide

Loop diuretic (sulfonamide)

13

Torsemide

Loop diuretic (sulfonamide)

14

Ethacrynic acid

Loop diuretic (not sulfonamide)

15

Furosemide
Mechanism of action

Inhibition of the Na/K/2Cl in the ascending limb of Henle's loop

16

Inhibition of the Na/K/2Cl in the ascending limb of Henle's loop

Furosemide
Mechanism of action

17

Loop diuretics
Mechanism of action

Inhibition of the Na/K/2Cl in the ascending limb of Henle's loop

18

Loop diuretics
Effects

-Marked increase in NaCl excretion
-Some K wasting
-Hypokalemic metabolic alkalosis
-Increased urine Ca and Mg

19

-Marked increase in NaCl excretion
-Some K wasting
-Hypokalemic metabolic alkalosis
-Increased urine Ca and Mg

Loop diuretics
Effects

20

Loop diuretics
Clinical applications

-Pulmonary edema.
-Peripheral edema.
-Hypertension.
-Acute hypercalcemia.
-Acute hyperkalemia.
-Renal failure anion overdose (bromide, fluoride,
and iodide.

21

-Pulmonary edema.
-Peripheral edema.
-Hypertension.
-Acute hypercalcemia.
-Acute hyperkalemia.
-Renal failure anion overdose (bromide, fluoride,
and iodide.

Loop diuretics
Clinical applications

22

Loop diuretics
Toxicity

Ototoxicity
Hypovolemia
K wasting
Hyperuricemia
Hypomagnesemia

23

Thiazide diuretics

Hydrochlorothiazide
Chlorothiazide
Bendroflumethiazide
Hydroflumethazide
Methyclothiazide
Indapamide

24

Hydrochlorothiazide

Thiazide diuretic

25

Chlorothiazide

Thiazide diuretic

26

Hydroflumethazide

Thiazide diuretic

27

Methyclothiazide

Thiazide diuretic

28

Indapamide

Thiazide diuretic

29

Thiazide diuretic
Mechanism of action

Inhibition of the Na/Cl transporter in the distal convoluted tubule