Aminoglycosides Flashcards Preview

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Flashcards in Aminoglycosides Deck (24):
0

Aminoglycosides

Gentamicin
Tobramycin
Amikacin
Streptomycin
Neomycin

1

Gentamicin

Aminoglycoside

2

Tobramycin

Aminoglycoside

3

Amikacin

Aminoglycoside

4

Streptomycin

Aminoglycoside

5

Neomycin

Aminoglycoside

6

Gentamicin
(Aminoglycosides)

Mechanism of action

Prevent bacterial protein synthesis by binding to the 30S ribosomal subunit

7

Prevent bacterial protein synthesis by binding to the 30S ribosomal subunit

Gentamicin
(Aminoglycosides)

Mechanism of action

8

Gentamicin
(Aminoglycosides)

Effects

Bactericidal activity agains susceptible bacteria, synergistic effects against gram-positive bacteria when combined with Beta-lactams or vancomycin, concentration-dependent killing and a significant post-antibiotic effect

9

Bactericidal activity agains susceptible bacteria, synergistic effects against gram-positive bacteria when combined with Beta-lactams or vancomycin, concentration-dependent killing and a significant post-antibiotic effect

Gentamicin
(Aminoglycosides)

Effects

10

Gentamicin
(Aminoglycosides)

Clinical applications

Sepsis caused by aerobic gram-negative bacteria, synergistic activity in endocarditis caused by streptococci, staphylococci and enterococci

11

Sepsis caused by aerobic gram-negative bacteria, synergistic activity in endocarditis caused by streptococci, staphylococci and enterococci

Gentamicin
(Aminoglycosides)

Clinical applications

12

Gentamicin
(Aminoglycosides)

Pharmacokinetics, Toxicities, Interactions

IV, renal clearance (half-life 2.5 h) once-daily dosing as effective and may have less toxicity then conventional dosing, TOXICITY: Nephrotoxicity (reverible), ototoxicity (irreversible), neuromuscular blockade

13

IV, renal clearance (half-life 2.5 h) once-daily dosing as effective and may have less toxicity then conventional dosing, TOXICITY: Nephrotoxicity (reverible), ototoxicity (irreversible), neuromuscular blockade

Gentamicin
(Aminoglycosides)

Pharmacokinetics, Toxicities, Interactions

14

Tobramycin

Quality

Intravenous; more active then gentamicin versus Pseudomonas; may also have less nephrotoxicity

15

Intravenous; more active then gentamicin versus Pseudomonas; may also have less nephrotoxicity

Tobramycin

Quality

16

Amikacin

Quality

Intravenous; resistant to many ezymes that inactivate gentamicin and tobramycin; higher doses and target peak and troughs than gentamicin and tobramycin

17

Intravenous; resistant to many ezymes that inactivate gentamicin and tobramycin; higher doses and target peak and troughs than gentamicin and tobramycin

Amikacin

Quality

18

Streptomycin

Quality

Intramuscular; widespread resistance limits use to specific indications such as tuberculosis and enterococcal endocarditis

19

Intramuscular; widespread resistance limits use to specific indications such as tuberculosis and enterococcal endocarditis

Streptomycin

Quality

20

Neomycin

Quality

Oral or topical, poor bioavailability; used before bowel surgery to decrease aerobic flora; also used to treat hepatic encephalopathy

21

Oral or topical, poor bioavailability; used before bowel surgery to decrease aerobic flora; also used to treat hepatic encephalopathy

Neomycin

Quality

22

Spectinomycin

Quality

Intramuscular; sole use is for treatment of antibiotic-resistant gonococcal infections or gonococcal infections in penicillin-allergic patients

23

Intramuscular; sole use is for treatment of antibiotic-resistant gonococcal infections or gonococcal infections in penicillin-allergic patients

Spectinomycin

Quality