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Flashcards in Sedative-Hypnotic Drugs Deck (53)
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Benzodiazepines

Alprazolam
Chlordiazepoxide
Clonazepam
Diazepam
Lorazepam
Triazolam

1

Alprazolam

Benzodiazepine

2

Chlordiazepoxide

Benzodiazepine

3

Clonazepam

Benzodiazepine

4

Diazepam

Benzodiazepine

5

Lorazepam

Benzodiazepine

6

Lorazepam

Benzodiazepine

7

Diazepam
Lorazepam

Mechanism of action

Bind to specific GABA(A) receptor subunits at central nervous system (CNS) neuronal synapses facilitating frequency of GABA-mediated chloride ion channel opening- enhance membrane hyperpolarization

8

Bind to specific GABA(A) receptor subunits at central nervous system (CNS) neuronal synapses facilitating frequency of GABA-mediated chloride ion channel opening- enhance membrane hyperpolarization

Diazepam
Lorazepam

Mechanism of action

9

Diazepam
Lorazepam

Effects

Dose-dependent depressant effect on the CNS including sedation and relief of anxiety, Amnesia, Hypnosis, Anesthesia, Coma and Respiratory depression

10

Dose-dependent depressant effect on the CNS including sedation and relief of anxiety, Amnesia, Hypnosis, Anesthesia, Coma and Respiratory depression

Diazepam
Lorazepam

Effects

11

Diazepam
Lorazepam

Clinical applications

Acute anxiety states, Panic attacks, Generalized anxiety disorder, Insomnia and other sleep disorders, Relaxation of skeletal muscle, Anesthesia (adjunctive) Seizure disorders

12

Acute anxiety states, Panic attacks, Generalized anxiety disorder, Insomnia and other sleep disorders, Relaxation of skeletal muscle, Anesthesia (adjunctive) Seizure disorders

Diazepam
Lorazepam

Clinical applications

13

Diazepam
Lorazepam
(Benzodiazepines in general)

Pharmacokinetics, Toxicities, Interactions

Half-lives from 2-40 h, Oral activity, Hepatic metabolism-some active metabolites, TOXICITY: extensions of CNS depressant effects, dependence liability, INTERACTIONS: Additive CNS depression with ethanol and many other drugs

14

Half-lives from 2-40 h, Oral activity, Hepatic metabolism-some active metabolites, TOXICITY: extensions of CNS depressant effects, dependence liability, INTERACTIONS: Additive CNS depression with ethanol and many other drugs

Diazepam
Lorazepam
(Benzodiazepines in general)

Pharmacokinetics, Toxicities, Interactions

15

Benzodiazepine antagonist

Flumazenil

16

Flumazenil

Benzodiazepine antagonist

17

Flumazenil

Mechanism of action

Antagonist at benzodiazepine binding sites on the GABA(A) receptor

18

Antagonist at benzodiazepine binding sites on the GABA(A) receptor

Flumazenil

Mechanism of action

19

Flumazenil

Effects

Blocks actions of benzodiazepines and zolpidem but not other sedative-hypnotic drugs

20

Blocks actions of benzodiazepines and zolpidem but not other sedative-hypnotic drugs

Flumazenil

Effects

21

Flumazenil

Clinical applications

Management of benzodiazepine overdose

22

Management of benzodiazepine overdose

Flumazenil

Clinical applications

23

Flumazenil

Pharmacokinetics, Toxicities, Interactions

IV, short half-life, TOXICITY: Agitation, Confusion, Possible withdrawal symptoms in benzodiazepine dependence

24

IV, short half-life, TOXICITY: Agitation, Confusion, Possible withdrawal symptoms in benzodiazepine dependence

Flumazenil

Pharmacokinetics, Toxicities, Interactions

25

Barbiturates

Amobarbital
Butabarbital
Mephobarbital
Pentobarbital
Phenobarbital
Secobarbital

26

Amobarbital

Barbiturate

27

Butabarbital

Barbiturate

28

Barbiturate

Barbiturate

29

Mephobarbital

Barbiturate