Drugs Used In Thyroid Disease Flashcards Preview

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Flashcards in Drugs Used In Thyroid Disease Deck (37):
0

Thyroid preperations

Levothyroxine (T4)
Liothyronine (T3)

1

Levothyroxine (T4)

Thyroid preperation

2

Liothyronine (T3)

Thyroid preperation

3

Levothyroxine (T4)
Mechanism of action and effects

Activation of nuclear receptors results in gene expression with RNA formation and protein synthesis

4

Activation of nuclear receptors results in gene expression with RNA formation and protein synthesis

Levothyroxine (T4)
Mechanism of action and effects

5

Levothyroxine (T4)
Indications

Hypothyroidism

6

Hypothyroidism

Levothyroxine (T4)
Indications

7

Antithyroid agents (thioamides)

Methimazole
Propylthiouracil (PTU)

8

Propylthiouracil (PTU)

Antithyroid agent (thioamide)

9

Methimazole

Antithyroid agent (thioamide)

10

Methimazole
Propylthiouracil (PTU)

Mechanism of action and effects

Inhibit thyroid peroxidase reaction
Block iodine organification
Inhibit perpheral deiodination of T4 and T3 (primarily PTU)

11

Inhibit thyroid peroxidase reaction
Block iodine organification
Inhibit perpheral deiodination of T4 and T3 (primarily PTU)

Methimazole
Propylthiouracil (PTU)

Mechanism of action and effects

12

Methimazole
Propylthiouracil

Indications

Hyperthyroidism

13

Hyperthyroidism

Methimazole
Propylthiouracil

Indications

14

Methimazole
Propylthiouracil

Toxicity

Nausea
Gastrointestinal distress
Rash
Agranulocytosis
Hepatitis
(PTU black box)
Hypothyroidism

15

Nausea
Gastrointestinal distress
Rash
Agranulocytosis
Hepatitis
(PTU black box)
Hypothyroidism

Methimazole
Propylthiouracil

Toxicity

16

Iodides

Lugol solution
Potassium iodide

17

Lugol solution

Iodide

18

Potassium iodide

Iodide

19

Lugol solution
Potassium iodide

Mechanism of action and effects

Inhibits organification and hormone release
Reduce the size and vascularity of the gland

20

Inhibits organification and hormone release
Reduce the size and vascularity of the gland

Lugol solution
Potassium iodide

Mechanism of action and effects

21

Lugol solution
Potassium iodide

Indications

Preperation for surgical thyroidectomy

22

Preperation for surgical thyroidectomy

Lugol solution
Potassium iodide

Indications

23

Beta blocker

Propranolol

24

Propranolol

Beta blocker

25

Propranolol
Mechanism of action and effects (in thyroid disease)

Inhibition of Beta adrenoreceptors
Inhibit T4 to T3 conversion (only propranolol)

26

Inhibition of Beta adrenoreceptors
Inhibit T4 to T3 conversion

Propranolol
Mechanism of action and effect ( in thyroid disease)

27

Propranolol
Indication (in thyroid disease)

Hyperthyroidism, especially thyroid storm
Adjunct to control tachcardia, hypertension and atrial fibrillation

28

Hyperthyroidism, especially thyroid storm
Adjunct to control tachcardia, hypertension and atrial fibrillation

Propranolol
Indication (in thyroid disease)

29

Propranolol
Toxicity (in thyroid disease)

Asthma
AV blockade
Hypotension
Bradycardia

30

Asthma
AV blockade
Hypotension
Bradycardia

Propranolol
Toxicity (in thyroid disease)

31

Radioactive iodine 131 I (RAI)
Mechanism of action and effects

Radiation destruction of thyroid parenchyma

32

Radiation destruction of thyroid parenchyma

Radioactive iodine 131 I (RAI)
Mechanism of action and effects

33

Radioactive iodine 131 I (RAI)
Indications

Hyperthyroidism
Patients should be euthyroid or on Beta blockers before RAI
Avoid in pregnancy or in nursing mothers

34

Hyperthyroidism
Patients should be euthyroid or on Beta blockers before RAI
Avoid in pregnancy or in nursing mothers

Radioactive iodine 131 I (RAI)
Indications

35

Radioactive iodine 131 I (RAI)
Toxicity

Sore throat
Sialitis
Hypothyroidism

36

Sore throat
Sialitis
Hypothyroidism

Radioactive iodine 131 I (RAI)
Toxicity