Drugs Used In Thyroid Disease Flashcards

(37 cards)

0
Q

Levothyroxine (T4)

A

Thyroid preperation

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1
Q

Thyroid preperations

A

Levothyroxine (T4)

Liothyronine (T3)

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2
Q

Liothyronine (T3)

A

Thyroid preperation

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3
Q

Levothyroxine (T4)

Mechanism of action and effects

A

Activation of nuclear receptors results in gene expression with RNA formation and protein synthesis

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4
Q

Activation of nuclear receptors results in gene expression with RNA formation and protein synthesis

A

Levothyroxine (T4)

Mechanism of action and effects

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5
Q

Levothyroxine (T4)

Indications

A

Hypothyroidism

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6
Q

Hypothyroidism

A

Levothyroxine (T4)

Indications

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7
Q

Antithyroid agents (thioamides)

A

Methimazole

Propylthiouracil (PTU)

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8
Q

Propylthiouracil (PTU)

A

Antithyroid agent (thioamide)

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9
Q

Methimazole

A

Antithyroid agent (thioamide)

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10
Q

Methimazole
Propylthiouracil (PTU)

Mechanism of action and effects

A

Inhibit thyroid peroxidase reaction
Block iodine organification
Inhibit perpheral deiodination of T4 and T3 (primarily PTU)

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11
Q

Inhibit thyroid peroxidase reaction
Block iodine organification
Inhibit perpheral deiodination of T4 and T3 (primarily PTU)

A

Methimazole
Propylthiouracil (PTU)

Mechanism of action and effects

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12
Q

Methimazole
Propylthiouracil

Indications

A

Hyperthyroidism

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13
Q

Hyperthyroidism

A

Methimazole
Propylthiouracil

Indications

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14
Q

Methimazole
Propylthiouracil

Toxicity

A
Nausea
Gastrointestinal distress
Rash
Agranulocytosis
Hepatitis
(PTU black box)
Hypothyroidism
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15
Q
Nausea
Gastrointestinal distress
Rash
Agranulocytosis
Hepatitis
(PTU black box)
Hypothyroidism
A

Methimazole
Propylthiouracil

Toxicity

16
Q

Iodides

A

Lugol solution

Potassium iodide

17
Q

Lugol solution

18
Q

Potassium iodide

19
Q

Lugol solution
Potassium iodide

Mechanism of action and effects

A

Inhibits organification and hormone release

Reduce the size and vascularity of the gland

20
Q

Inhibits organification and hormone release

Reduce the size and vascularity of the gland

A

Lugol solution
Potassium iodide

Mechanism of action and effects

21
Q

Lugol solution
Potassium iodide

Indications

A

Preperation for surgical thyroidectomy

22
Q

Preperation for surgical thyroidectomy

A

Lugol solution
Potassium iodide

Indications

23
Q

Beta blocker

24
Propranolol
Beta blocker
25
Propranolol | Mechanism of action and effects (in thyroid disease)
Inhibition of Beta adrenoreceptors | Inhibit T4 to T3 conversion (only propranolol)
26
Inhibition of Beta adrenoreceptors | Inhibit T4 to T3 conversion
Propranolol | Mechanism of action and effect ( in thyroid disease)
27
Propranolol | Indication (in thyroid disease)
Hyperthyroidism, especially thyroid storm | Adjunct to control tachcardia, hypertension and atrial fibrillation
28
Hyperthyroidism, especially thyroid storm | Adjunct to control tachcardia, hypertension and atrial fibrillation
Propranolol | Indication (in thyroid disease)
29
Propranolol | Toxicity (in thyroid disease)
Asthma AV blockade Hypotension Bradycardia
30
Asthma AV blockade Hypotension Bradycardia
Propranolol | Toxicity (in thyroid disease)
31
Radioactive iodine 131 I (RAI) | Mechanism of action and effects
Radiation destruction of thyroid parenchyma
32
Radiation destruction of thyroid parenchyma
Radioactive iodine 131 I (RAI) | Mechanism of action and effects
33
Radioactive iodine 131 I (RAI) | Indications
Hyperthyroidism Patients should be euthyroid or on Beta blockers before RAI Avoid in pregnancy or in nursing mothers
34
Hyperthyroidism Patients should be euthyroid or on Beta blockers before RAI Avoid in pregnancy or in nursing mothers
Radioactive iodine 131 I (RAI) | Indications
35
Radioactive iodine 131 I (RAI) | Toxicity
Sore throat Sialitis Hypothyroidism
36
Sore throat Sialitis Hypothyroidism
Radioactive iodine 131 I (RAI) | Toxicity