Flashcards in GI Drugs Deck (137)
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Drugs used in acid-peptic diseases
Proton pump inhibitors
H2-receptor blockers
Sucralfate
Antacids
1
Proton pump inhibitors
H2-receptor blockers
Sucralfate
Antacids
Drugs used in acid-peptic diseases
2
Proton pump inhibitors
Omeprazole
Lansoprazol
Etc
3
Omeprazole
Proton pump inhibitor
4
Lansoprazol
Proton pump inhibitor
5
Proton pump inhibitors
Mechanism of action
Irreversible blockade of H+/K+ATPase pump in active parietal cells of stomach
6
Irreversible blockade of H+/K+ATPase pump in active parietal cells of stomach
Proton pump inhibitors
Mechanism of action
7
Proton pump inhibitors
Effects
Long-lasting reduction of stimulating and nocturnal acid secretion
8
Long-lasting reduction of stimulating and nocturnal acid secretion
Proton pump inhibitors
Effects
9
Proton pump inhibitors
Clinical applications
Peptic ulcer
Gastroesophageal reflux disease
Erosive gastritis
10
Peptic ulcer
Gastroesophageal reflux disease
Erosive gastritis
Proton pump inhibitors
Clinical applications
11
Proton pump inhibitors
Toxicities
Reduction of stomach acid may reduce absorbtion of some drugs and increase that of others
12
Reduction of stomach acid may reduce absorbtion of some drugs and increase that of others
Proton pump inhibitors
Toxicities
13
H2-receptors blockers
Cimetidine
Etc
14
H2-receptors blockers
Cimetidine
Etc
15
H2-receptors blockers
Effects
Effective reduction of nocturnal acid but less effective against stimulated secretion, very safe.
16
Effective reduction of nocturnal acid but less effective against stimulated secretion, very safe.
H2-receptors blockers
Effects
17
Sucralfate
Effects
Polymerizes at site of tissue damage (ulcer bed) and protectsagainst further damage; very insoluble with no systemic effects; must be given 4 times daily
18
Polymerizes at site of tissue damage (ulcer bed) and protectsagainst further damage; very insoluble with no systemic effects; must be given 4 times daily
Sucralfate
Effects
19
Antacids
Effects
Popular OTC medication for symtomatic relief of heartburn; not as usful as PPI and H2 blockers in peptic diseases
20
Popular OTC medication for symtomatic relief of heartburn; not as usful as PPI and H2 blockers in peptic diseases
Antacids
Effects
21
Drugs stimulating motility
Metoclopramid
Domperidone
Cholibomimetics: Neostigmine
Macrolides: Eryhromycin
22
Metoclopramid
Domperidone
Cholibomimetics: Neostigmine
Macrolides: Eryhromycin
Drugs stimulating motility
23
Drugs stimulating motility
Metoclopramid
Domperidone
Mechanism of action
D2-receptor blocker
Removes inhibition of acetylcholine neurons in enteric nervous system
24
D2-receptor blocker
Removes inhibition of acetylcholine neurons in enteric nervous system
Drugs stimulating motility
Metoclopramid
Domperidone
Mechanism of action
25
Drugs stimulating motility
Metoclopramid
Domperidone
Effects
Increases gastric emptying and intestinal mobility
26
Drugs stimulating motility
Metoclopramid
Domperidone
Effects
Increases gastric emptying and intestinal mobility
27
Drugs stimulating motility
Metoclopramid
Domperidone
Clinical applications
Gastric paresis (e.g, in diabetic)
Antiemetic
28
Gastric paresis (e.g, in diabetic)
Antiemetic
Drugs stimulating motility
Metoclopramid
Domperidone
Clinical applications
29
