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Flashcards in GI Drugs Deck (137)
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Drugs used in acid-peptic diseases

Proton pump inhibitors
H2-receptor blockers
Sucralfate
Antacids

1

Proton pump inhibitors
H2-receptor blockers
Sucralfate
Antacids

Drugs used in acid-peptic diseases

2

Proton pump inhibitors

Omeprazole
Lansoprazol
Etc

3

Omeprazole

Proton pump inhibitor

4

Lansoprazol

Proton pump inhibitor

5

Proton pump inhibitors
Mechanism of action

Irreversible blockade of H+/K+ATPase pump in active parietal cells of stomach

6

Irreversible blockade of H+/K+ATPase pump in active parietal cells of stomach

Proton pump inhibitors
Mechanism of action

7

Proton pump inhibitors
Effects

Long-lasting reduction of stimulating and nocturnal acid secretion

8

Long-lasting reduction of stimulating and nocturnal acid secretion

Proton pump inhibitors
Effects

9

Proton pump inhibitors
Clinical applications

Peptic ulcer
Gastroesophageal reflux disease
Erosive gastritis

10

Peptic ulcer
Gastroesophageal reflux disease
Erosive gastritis

Proton pump inhibitors
Clinical applications

11

Proton pump inhibitors
Toxicities

Reduction of stomach acid may reduce absorbtion of some drugs and increase that of others

12

Reduction of stomach acid may reduce absorbtion of some drugs and increase that of others

Proton pump inhibitors
Toxicities

13

H2-receptors blockers

Cimetidine
Etc

14

H2-receptors blockers

Cimetidine
Etc

15

H2-receptors blockers
Effects

Effective reduction of nocturnal acid but less effective against stimulated secretion, very safe.

16

Effective reduction of nocturnal acid but less effective against stimulated secretion, very safe.

H2-receptors blockers
Effects

17

Sucralfate
Effects

Polymerizes at site of tissue damage (ulcer bed) and protectsagainst further damage; very insoluble with no systemic effects; must be given 4 times daily

18

Polymerizes at site of tissue damage (ulcer bed) and protectsagainst further damage; very insoluble with no systemic effects; must be given 4 times daily

Sucralfate
Effects

19

Antacids
Effects

Popular OTC medication for symtomatic relief of heartburn; not as usful as PPI and H2 blockers in peptic diseases

20

Popular OTC medication for symtomatic relief of heartburn; not as usful as PPI and H2 blockers in peptic diseases

Antacids
Effects

21

Drugs stimulating motility

Metoclopramid
Domperidone
Cholibomimetics: Neostigmine
Macrolides: Eryhromycin

22

Metoclopramid
Domperidone
Cholibomimetics: Neostigmine
Macrolides: Eryhromycin

Drugs stimulating motility

23

Drugs stimulating motility
Metoclopramid
Domperidone

Mechanism of action

D2-receptor blocker
Removes inhibition of acetylcholine neurons in enteric nervous system

24

D2-receptor blocker
Removes inhibition of acetylcholine neurons in enteric nervous system

Drugs stimulating motility
Metoclopramid
Domperidone

Mechanism of action

25

Drugs stimulating motility
Metoclopramid
Domperidone

Effects

Increases gastric emptying and intestinal mobility

26

Drugs stimulating motility
Metoclopramid
Domperidone

Effects

Increases gastric emptying and intestinal mobility

27

Drugs stimulating motility
Metoclopramid
Domperidone

Clinical applications

Gastric paresis (e.g, in diabetic)
Antiemetic

28

Gastric paresis (e.g, in diabetic)
Antiemetic

Drugs stimulating motility
Metoclopramid
Domperidone

Clinical applications

29

Drugs stimulating motility
Metoclopramid
Domperidone

Toxicities

Parkinsonian symtoms due to block of central nervous system (CNS) D2 receptors