Cancer Chemotherapy Flashcards Preview

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Flashcards in Cancer Chemotherapy Deck (20):
0

Alkylating agent
Cytotoxic effect via transfer of alkyl groups to various cellular constitutents
Cell-cycle-nonspecific (CCNS) agent

Cyclophosphamide

1

Cyclophosphamide

Alkylating agent
Cytotoxic effect via transfer of alkyl groups to various cellular constitutents
Cell-cycle-nonspecific (CCNS) agent

2

Recombinant humanized monoclonial antibody that targets all forms of VEGF-A

Anti angiogenic

Bevacizumab

3

Bevacizumab

Recombinant humanized monoclonial antibody that targets all forms of VEGF-A

Anti angiogenic

4

Infliximab

Human-mouse chineric IgG1 monoclonial antibody

Bind TNF-a, ( a proinflamatory cytokine importent in inflammatory diseases)

5

Human-mouse chineric IgG1 monoclonial antibody

Bind TNF-a, ( a proinflamatory cytokine importent in inflammatory diseases)

Infliximab

6

Anakinra

Recombinant form of IL-1 receptor antagonist

7

Recombinant form of IL-1 receptor antagonist

Anakinra

8

Oxaliplatin

3rd generation platinum analog
Cytotoxic effect similar to alkylating agent, kill tumor cells in all stages of the cell cycle and bind DNA by forming intrastrand and interstrand cross-links, inhibiting DNA synthesis

9

3rd generation platinum analog
Cytotoxic effect similar to alkylating agent, kill tumor cells in all stages of the cell cycle and bind DNA by forming intrastrand and interstrand cross-links, inhibiting DNA synthesis

Oxaliplatin

10

5-Fluorouracil (5-FU)

Fluoropyrimidine
Anti-metabolite, interferes with DNA and RNA syntesis
Most widely used agent in the treatment of colorectal cancer

11

Fluoropyrimidine
Anti-metabolite, interferes with DNA and RNA syntesis
Most widely used agent in the treatment of colorectal cancer

5-Fluorouracil (5-FU)

12

Vincristine

Alkaloid derived from the plant Vinca rosea
Inhibits tubulin polymerization, leads to mitotic arrest in metaphase
Cell-cycle-specific (CCS) agent

Hematologic malignancies

13

Alkaloid derived from the plant Vinca rosea
Inhibits tubulin polymerization, leads to mitotic arrest in metaphase
Cell-cycle-specific (CCS) agent

Hematologic malignancies

Vincristine

14

Paclitaxel

Alkaloid ester derrived from Taxus brevifolia and Taxus baccata
Mitotic spindle poison

Solid tumors

15

Alkaloid ester derrived from Taxus brevifolia and Taxus baccata
Mitotic spindle poison

Solid tumors

Paclitaxel

16

Etoposide

Epipodophyllotoxin
Inhibition of topoisomerase II

Small cell cancer, etc

17

Epipodophyllotoxin
Inhibition of topoisomerase II

Small cell cancer, etc

Etoposide

18

Doxorubicin

Anthracycline
Cytotoxic antcancer drug
Inhibits topoisomerase II, bind DNA, free radical production, bind cellular membranes

19

Anthracycline
Cytotoxic antcancer drug
Inhibits topoisomerase II, bind DNA, free radical production, bind cellular membranes

Doxorubicin