Anaerobic Gram-negative rods (Bacteroides, Fusobacterium, Prevotella, Porphyromonas)

Question 1

General Info

Answer 1

• Normal microbiota in oral cavity & colon
• Obligate Anaerobic

Question 2

Morphology

Answer 2

• Gram Negative
• Rods
• Very thin & long

Question 3

Cultivation

Answer 3

• Obligate Anaerobic
• Oxygen is Toxic to them
• Characteristic Foul smell

Question 4

Types of Bacteroides

Answer 4

• B. Fragalis
• B. Distanosis

Question 5

B. Fragalis info

Answer 5

• 40% of Colon microbiota
• Cultivated on Bile-esculin agar

Question 6

B. Fragalis Virulence factors

Answer 6

• Polysaccharide capsule
• Superoxide Dismutase
• Hyaluronidase, Fibrinolysin, DNase, Heparinase

Question 7

B. Fragalis Infections

Answer 7

• Intraabdominal Infections after bowel perforation
• Nosocomial wound infections (SSIs)

Question 8

Fusobacteria Types

Answer 8

• F. Nucleatum
• F. Necrophorum
• F. Varium

Question 9

F. Nucleatum info

Answer 9

• Oral cavity microbiota
• In gingival sulcus

Question 10

F. Nucleatum Diseases

Answer 10

• Plaut-Vincent Angina
• Dental Plaque
• Periodontal disease, Gingivitis
• Tonsilitis
• Aspiration Pneumonia

Question 11

Plaut-Vincent Angina

Answer 11

• Mixed infection with of F. Nucleatum + Treponema Vincentii
• Unilateral infection of Throat & oral cav.
• Ulcer, pain

Question 12

Aspiration Pneumonia

Answer 12

Inhaling something causing bronchiole blockage making anaerobic condition harboring these anaerobic bacteria

Question 13

F. Necrophorum

Answer 13

Causes Lemierre Syndrome = Acute oropharyngeal infection

Question 14

Prevotella Types

Answer 14

• P. Melaningenica
• P. Bivia
• P. Intermedia

Question 15

P. Intermedia info

Answer 15

Oral Cavity microbiota

Question 16

P. Intermedia Virulence factors

Answer 16

• IgA protease
• Collagenase, Fibrinolysin

Question 17

P. Intermedia Diseases

Answer 17

• Aspiration Pneumonia
• Abscesses
• Periodontal disease, Gingivitis
• Bacterial Vaginosis

Question 18

Porphyromonas Types

Answer 18

• P. Gingivalis
• P. Asaccharolytica

Question 19

P. Gingivalis info

Answer 19

Part of Oral Microbiota

Question 20

P. Gingivalis Virulence

Answer 20

• Trypsin-like activity
• Collagenase

Question 21

P. Gingivalis Diseases

Answer 21

Same as prevotella
- Aspiration Pneumonia
- Abscesses
- Periodontal disease, Gingivitis
- Bacterial Vaginosis

Question 22

Treatment of Anaerobic Infections

Answer 22

• Metronidazole
• Cephalosporins
• Carbapenems