Chlamydia, Rickettsiae, Orienta, Coxiella, Mycoplasma, Ureaplasma Flashcards
(24 cards)
Chlamydia Genus info
- Obligate Intracellular
- Cell wall no peptidoglycan (muramic acid)
- Cant use B-lactams
- Most common STI
- Biphasic Lifestyle: 1- Elementary body, 2- Reticulate body (rep)
Chlamydia Trachomatis Serotypes
- A-C: Blindness/Trachoma
- D-K: STI, watery discharge
- L1-L3: Lymphogranuloma Venarum (LGV)
Chlamydophilia Pneumoniae
- Spread by respiratory droplets
- Atypical Pneumonia
- Non-productive cough
- Ab serology, PCR
- Aminoglycosides could be used here
Chlamydophilia Psittaci
- Feces of birds
- Parrot Fever (psittacosis)
- Atypical Pneumonia
- Non-productive cough
Chlamydia Treatments
- Macrolides/Azithromycin
- Doxycyline
- Ceftriaxone (early when gonorrhea suspected
Ricketsiae, Orienta, Coxiella Common features
- Obligate I.C
- Gram Negative
- Spread by Vectors (insects)
Rickettsia Species
- R. Rickettsii
- R. Akari
- R. Prowazekii
- R. Typhi
(coccobacilli)
Rickettsia Rickettsii
- Rocky Mountain Spotted Fever
- Tick Bite spread
- Fever, Headache, Myalgia
- Maculopapular rash from extremities to torso
- Meningitis
Rickettsia Akari
- Rickettsialpox
- PCR from blood to confirm
- Doxycycline
Rickettsia Prowazekii
- Epidemic Thyphus
- Body louse faeces scratched in
- Headache, Fever, pneumonia
- Rash, Vasculitis
- Meningoencephalitis, coma
- Brill Zinsser Disease (reactivation)
Rickettsia Typhi
- Endemic Typhus
- Rodent reservoir
- Flea vector
- Similar to prowazekii but less severe
Rickettsia Diagnosis
Weil-Felix Tube agglutination
- Abs from blood
- Cross-reaction with proteus antigens
- PCR
Rickettsia Treatment
Doxycycline
Orienta Tsutsugamushi Info
- Transmitted by Chiggers (larval mites)
- Targets endothelial, phagocytic cells
Orienta Disease
Scrub Typhus
- Found in Asia-pacific region known as tsutsugamushi triangle
- Fever, Headache, lymphadenopathy, eschar, maculopapular rash, splenomegaly
Orienta Diagnosis & Treatment
- Wiel-Felix Agglutination
- Doxycycline
Coxiella Burnetti Info
- Tick spread among animals
- Human infection is Airborne (aerosol) from poop infected
- Replicates I.C in macrophages & monocytes = Obligate I.C
Coxiella Disease
Q-Fever
- Acute: Flu-like, fever, headache, myalgia, can form atypical Pneumonia or Hepatitis
- Chronic (rare): Endocarditis & long time fever
Coxiella Treatment & Diagnosis
- Acute: Doxycycline
- Chronic: Doxycycline + Rifampin or Fluoroquinolone
- Serology test
Mycoplasma & Ureaplasma Info
- Lack a Cell wall
- Resistant to B-lactams
- Epicellular (grow on surface of cells)
- Eaton Agar for Culturing
Mycoplasma Types
- M. Pneumoniae
- M. Genitalium
- M. Hominis
M. Pneumoniae
- Atypical/Walking Pneumonia
- Looks worse than it is = Patchy X-ray infiltrate
- Dry cough, low-grade fever, fatigue
- Macrolides or Docycycline
- PCR/NAAT or serology
M. Genitalium
Non-gonococcal Urethritis
- Men: Urethritis + Purulent discharge
- Women: Cervicitis + vaginal discharge + PID
- STI
M. Hominis & Ureaplasma Urealyticum
- Often found in Vagina & Urethra without issues
- Uncertain role in infections: PID, Vaginitis, NGU, Pregnancy infections
- Doxycycline or Fluoroquinolones NOT Macrolides (resistant)
- Genital swab PCR or cultivation in liquid medium
